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1606974-33-7

  • Product Name:Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
  • Molecular Weight:405.804
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Product Details

Purity:99%

Quality manufacturer supply Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- 1606974-33-7 in stock with high standard

  • Molecular Formula:C21H15ClF3NO2
  • Molecular Weight:405.804
  • Boiling Point:514.4±50.0 °C(Predicted) 
  • Density:1.351±0.06 g/cm3(Predicted) 

1606974-33-7 Relevant articles

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Gurney, Mark E.,Nugent, Richard A.,Mo, Xuesheng,Sindac, Janice A.,Hagen, Timothy J.,Fox, David,O'Donnell, James M.,Zhang, Chong,Xu, Ying,Zhang, Han-Ting,Groppi, Vincent E.,Bailie, Marc,White, Ronald E.,Romero, Donna L.,Vellekoop, A. Samuel,Walker, Joel R.,Surman, Matthew D.,Zhu, Lei,Campbell, Robert F.

, p. 4884 - 4901 (2019/05/16)

Novel pyridine- and pyrimidine-based all...

HETEROARYL INHIBITORS OF PDE4

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Paragraph 0746-0748, (2014/05/24)

The present invention relates to compoun...

1606974-33-7 Process route

methyl 2-(4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)phenyl)acetate

methyl 2-(4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)phenyl)acetate

4-chloro-2-(3-chlorophenyl)-6-(trifluoromethyl)pyridine
1606977-01-8

4-chloro-2-(3-chlorophenyl)-6-(trifluoromethyl)pyridine

methyl 2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetate
1606974-32-6

methyl 2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetate

2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)-1-(oxidaneyl)ethan-1-one
1606974-33-7

2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)-1-(oxidaneyl)ethan-1-one

Conditions
Conditions Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 27h; Sealed tube; Inert atmosphere;
4%
0.396 g
methyl 2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetate
1606974-32-6

methyl 2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetate

2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)-1-(oxidaneyl)ethan-1-one
1606974-33-7

2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)-1-(oxidaneyl)ethan-1-one

Conditions
Conditions Yield
With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃;
90%

1606974-33-7 Upstream products

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    13737-36-5

    4-bromophenylacetic acid

  • 7398-42-7
    7398-42-7

    methyl 2-(4-(bromomethyl)phenyl)acetate

  • 1606977-01-8
    1606977-01-8

    4-chloro-2-(3-chlorophenyl)-6-(trifluoromethyl)pyridine

  • 39891-02-6
    39891-02-6

    2,4-dichloro-6-trifluoromethylpyridine

1606974-33-7 Downstream products

  • 1606974-36-0
    1606974-36-0

    2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetamide

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