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100361-18-0

Q: What is the CAS number for 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid?

The CAS number of 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid is 100361-18-0.

Product Name:7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Molecular Formula:C₁₂H₈FClN₂O₃
Molecular Weight:282.659
Appearance:White powder

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Product Details

pd_meltingpoint:209-212 °C

Appearance:White powder

Purity:99%

99% Purity Commercial production 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 100361-18-0 with Cheapest Price

Molecular Formula:C12H8FClN2O3
Molecular Weight:282.659
Appearance/Colour:White powder
Vapor Pressure:0mmHg at 25°C
Melting Point:209-212 °C
Refractive Index:1.692
Boiling Point:485.919 °C at 760 mmHg
PKA:5.96±0.70(Predicted)
Flash Point:247.675 °C
PSA：72.19000
Density:1.727 g/cm³
LogP:2.22210

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(Cas 100361-18-0) Usage

InChI:InChI=1/C12H8ClFN2O3/c13-10-8(14)3-6-9(17)7(12(18)19)4-16(5-1-2-5)11(6)15-10/h3-5H,1-2H2,(H,18,19)

100361-18-0 Relevant articles

Quinolone Antibacterials Containing the New 7- Side Chain: The Effects of the 1-Aminoethyl Moiety and Its Stereochemical Configurations on Potency and in Vivo Efficacy

Domagala, John M.,Hagen, Susan E.,Joannides, Themis,Kiely, John S.,Laborde, Edgardo,et al.

, p. 871 - 882 (1993)

A series of stereochemically pure 7--1,4...

Novel lead generation of an anti-tuberculosis agent active against non-replicating mycobacteria: Exploring hybridization of pyrazinamide with multiple fragments

Markad, Shankar D.,Kaur, Parvinder,Kishore Reddy,Chinnapattu, Murugan,Raichurkar, Anandkumar,Nandishaiah, Radha,Panda, Manoranjan,Iyer, Pravin S.

, p. 2986 - 2992 (2015/03/14)

The key to shortening tuberculosis (TB) ...

Structure aided design of chimeric antibiotics

Karoli, Tomislav,Mamidyala, Sreeman K.,Zuegg, Johannes,Fry, Scott R.,Tee, Ernest H.L.,Bradford, Tanya A.,Madala, Praveen K.,Huang, Johnny X.,Ramu, Soumya,Butler, Mark S.,Cooper, Matthew A.

supporting information; experimental part, p. 2428 - 2433 (2012/05/19)

The rise of antibiotic resistance is of ...

PROCESS FOR PREPARING 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID

-

Page/Page column 10-12, (2008/06/13)

Starting from ethyl 3-(2,6-dichloro-5-fl...

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1

Tomita, Kyoji,Tsuzuki, Yasunori,Shibamori, Koh-ichiro,Tashima, Masanori,Kajikawa, Fumie,Sato, Yuji,Kashimoto, Shigeki,Chiba, Katsumi,Hino, Katsuhiko

, p. 5564 - 5575 (2007/10/03)

In an attempt to search for clinically u...

100361-18-0 Process route

: 96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 122-51-0
orthoformic acid triethyl ester

: 765-30-0
Cyclopropylamine

: 100361-18-0
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic anhydride; triethylamine; Yield given. Multistep reaction;

: 96568-07-9
ethyl-7-chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 100361-18-0
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; water; In tetrahydrofuran; for 2h; Reflux; Inert atmosphere;	78%
With 20percent aq. HCl; Heating;
With hydrogenchloride; water; In toluene; for 8 - 10h; Product distribution / selectivity; Heating / reflux;

100361-18-0 Upstream products

96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate
122-51-0
orthoformic acid triethyl ester
765-30-0
Cyclopropylamine
96568-07-9
ethyl-7-chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

100361-18-0 Downstream products

113533-65-6
1-cyclopropyl-6-fluoro-1,4-dihydro-7-<3-<(methylamino)methyl>-1-pyrrolidinyl>-4-oxo-1,8-naphthyridine-3-carboxylic acid
175463-14-6
gemifloxacin
135026-90-3
3R,1S-7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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