Your Location：Home >Products >API >79416-27-6
pd_meltingpoint:119-121°
Purity:99%
|
Biochem/physiol Actions |
Methyl δ-aminolevulinate (methyl-ALA, MAL) and 5-Aminolevulinic acid (5-ALA) are commonly used in photosentizer reagents for photodynamic therapy to treat conditions such as Acne vulgaris and hypertrophic scarring. |
|
Definition |
ChEBI: The hydrochloride salt of methyl 5-aminolevulinate. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells. |
|
Brand name |
Metvixia (PhotoCure, Norway). |
InChI:InChI=1/C6H11NO3.ClH/c1-10-6(9)3-2-5(8)4-7;/h2-4,7H2,1H3;1H
Protoporphyrin IX (PpIX) is used as a ph...
The present invention discloses compound...
The present invention relates to compoun...
A route has been developed to high-purit...
methanol
5-aminolevulinic acid hydrochloride
methyl aminolevulinate
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
at 20 ℃;
for 30h;
|
86.3% |
|
With
thionyl chloride;
at 20 ℃;
for 48h;
|
81% |
|
With
thionyl chloride;
at 0 - 20 ℃;
|
|
|
With
thionyl chloride;
|
5-aminolevulinic acid hydrochloride
methyl aminolevulinate
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
methanol;
|
|
|
With
hydrogenchloride;
In
methanol;
|
methanol
5-aminolevulinic acid hydrochloride
ALA
methyl 5-bromo-4-oxopentanoate
methyl 5-((2'-tert-butyloxycarbonylamino)-L-phenylpropionyl)amino-4-oxopentanoate
5-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-4-oxo-pentanoic acid methyl ester
methyl 5-(4-methylphenylsulfonamido)-4-oxopentanoate
3-[2-((S)-1-Benzyloxycarbonylamino-3-methyl-butyl)-thiazol-5-yl]-propionic acid methyl ester
CAS：118685-33-9
CAS：6138-41-6
CAS：309271-94-1
CAS：140898-97-1
