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pd_meltingpoint:>300℃
Purity:99%
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General Description |
Phosphocitrate is a novel biochemical compound, consisting of a phosphorylated form of citrate, which has shown promising potential as a therapeutic agent in the treatment of various musculoskeletal disorders. Phosphocitrate has been found to inhibit the formation and growth of hydroxyapatite crystals that are responsible for the development of conditions such as osteoarthritis and kidney stone formation. Additionally, phosphocitrate has demonstrated anti-inflammatory and anti-catabolic properties, making it a potential candidate for the management of joint diseases and other related disorders. Its ability to modulate bone and cartilage metabolism, as well as its safety profile, make phosphocitrate a valuable target for further research and development in the field of musculoskeletal medicine. |
InChI:InChI=1/C6H9O10P/c7-3(8)1-6(5(11)12,2-4(9)10)16-17(13,14)15/h1-2H2,(H,7,8)(H,9,10)(H,11,12)(H2,13,14,15)
(Chemical Equation Presented) A novel me...
Phosphorylation of tribenzyl citrate wit...
Synthesis of glycolamide esters of phosp...
tribenzyl citrate
2-phosphonooxy-1,2,3-propane tricarboxylic acid
| Conditions | Yield |
|---|---|
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Multi-step reaction with 3 steps
1: PCl5 / benzene / 0.5 h / 5 °C
2: H2O / 0.5 h
3: H2 / Pd/C
With
phosphorus pentachloride; water; hydrogen;
palladium on activated charcoal;
In
benzene;
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Multi-step reaction with 5 steps
1: 1.) NaOH
3: H2 / Pd/C
4: H2 / PtO2
5: 90 percent / 0.17 h / pseudo-cholinesterase
With
sodium hydroxide; hydrogen;
platinum(IV) oxide; palladium on activated charcoal;
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Multi-step reaction with 5 steps
1: 1.) NaOH
3: H2 / Pd/C
4: H2 / PtO2
5: 90 percent / 0.17 h / pseudo-cholinesterase
With
sodium hydroxide; hydrogen;
platinum(IV) oxide; palladium on activated charcoal;
|
citric acid triethyl ester
2-phosphonooxy-1,2,3-propane tricarboxylic acid
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 4 steps
1: 100 percent Spectr. / Et3N / diethyl ether / 24 h / 20 °C
2: Et3N / diethyl ether / 20 °C
3: SO2Cl2 / diethyl ether / 1 h / 20 °C
4: HCl / 20 h / 38 - 40 °C
With
hydrogenchloride; sulfuryl dichloride; triethylamine;
In
diethyl ether;
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Multi-step reaction with 3 steps
1: pyridine
2: platinum; ethanol / Hydrogenation
3: aq. NaOH solution / Hydrogenation
With
pyridine; sodium hydroxide; ethanol; platinum;
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3-ethoxycarbonyl-3-phosphonooxypentanedioic acid diethyl ester
3-Carboxy-3-phosphonooxy-pentanedioic acid monodiethylcarbamoylmethyl ester
3-Carboxy-3-phosphonooxy-pentanedioic acid didiethylcarbamoylmethyl ester
1,3-dibenzyl-2-phosphonooxy citrate
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