What is the C 22 H 23 F 3 N 4 O 2 ?

C 22 H 23 F 3 N 4 O 2 is , while it's Molecular Formula is C 22 H 23 F 3 N 4 O 2 . ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2).

What is the CAS number for C 22 H 23 F 3 N 4 O 2 ?

The CAS number of C 22 H 23 F 3 N 4 O 2 is 1426916-02-0.

What is C 22 H 23 F 3 N 4 O 2 (1426916-02-0) used for?

ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity.

What is the C 22 H 23 F 3 N 4 O 2 ?

C 22 H 23 F 3 N 4 O 2 is , while it's Molecular Formula is C 22 H 23 F 3 N 4 O 2 . ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2).

What is the CAS number for C 22 H 23 F 3 N 4 O 2 ?

The CAS number of C 22 H 23 F 3 N 4 O 2 is 1426916-02-0.

What is C 22 H 23 F 3 N 4 O 2 (1426916-02-0) used for?

ML-298 is an inhibitor of phospholipase D2 (PLD2; IC50 = 355 nM). It is selective for PLD2 over PLD1 (IC50 = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity.

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1426916-02-0

Product Name:ML298
Molecular Weight:432.445

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Product Details

Purity:99%

Buy Quality ML298 1426916-02-0 In Stock with Immediately Delivery

Molecular Formula:C₂₂H₂₃F₃N₄O₂
Molecular Weight:432.445

1426916-02-0 Relevant articles

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: Discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells

O'Reilly, Matthew C.,Scott, Sarah A.,Brown, Kyle A.,Oguin, Thomas H.,Thomas, Paul G.,Daniels, J. Scott,Morrison, Ryan,Brown, H. Alex,Lindsley, Craig W.

supporting information, p. 2695 - 2699 (2013/05/22)

An iterative parallel synthesis effort i...

1426916-02-0 Process route

: 8-(2-aminoethyl)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4,5]decan-4-one dihydrochloride

: 76903-88-3
3,4-difluorobenzoyl chloride

: 1426916-02-0
C₂₂H₂₃F₃N₄O₂

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; at 20 ℃; Alkaline conditions;	80%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1426916-02-0
C₂₂H₂₃F₃N₄O₂

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: acetic acid / water / 12 h / 0 - 20 °C 1.2: 12 h / 0 - 20 °C 2.1: acetic acid / 0.25 h / 150 °C / Microwave irradiation 2.2: 3 h / Enzymatic reaction 3.1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 36 h 4.1: methanol; dichloromethane / 0.5 h / 20 °C 5.1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 36 h / 20 °C 6.1: N,N-dimethyl-formamide / 20 °C / Alkaline conditions With hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Yield

Multi-step reaction with 6 steps

1.1: acetic acid / water / 12 h / 0 - 20 °C

1.2: 12 h / 0 - 20 °C

2.1: acetic acid / 0.25 h / 150 °C / Microwave irradiation

2.2: 3 h / Enzymatic reaction

3.1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 36 h

4.1: methanol; dichloromethane / 0.5 h / 20 °C

5.1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 36 h / 20 °C

6.1: N,N-dimethyl-formamide / 20 °C / Alkaline conditions

With hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

1426916-02-0 Upstream products

76903-88-3
3,4-difluorobenzoyl chloride
3612-20-2
1-phenylmethyl-4-piperidone
372-19-0
meta-fluoroaniline
97861-33-1
1-(3-fluorophenyl)-1,3,8-triazaspiro<4.5>decan-4-one

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