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144564-94-3

  • Product Name:Boc-PNA-C(Z)-OH
  • Molecular Weight:503.512
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Product Details

Purity:99%

Manufacturer supply good quality Boc-PNA-C(Z)-OH 144564-94-3 with stock

  • Molecular Formula:C23H29N5O8
  • Molecular Weight:503.512

144564-94-3 Relevant articles

Synthesis of Peptide Nucleic Acid Monomers Containing the Four Natural Nucleobases: Thymine, Cytosine, Adenine, and Guanine and Their Oligomerization

Dueholm, Kim L.,Egholm, Michael,Behrens, Carsten,Christensen, Leif,Hansen, Henrik F.,et al.

, p. 5767 - 5773 (2007/10/02)

The preparation of mixed-sequence PNAs (...

Recognition of Guanine and Adenine in DNA by Cytosine and Thymine Containing Peptide Nucleic Acid (PNA)

Egholm, Michael,Nielsen, Peter E.,Buchardt, Ole,Berg, Rolf H.

, p. 9677 - 9678 (2007/10/02)

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144564-94-3 Process route

ethyl N-((N-<sup>4</sup>-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate
938175-07-6

ethyl N-((N-4-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

N-((N-<sup>4</sup>-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine
144564-94-3

N-((N-4-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Conditions
Conditions Yield
With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.25h;
69%
With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃;
N-benzyloxycarbonyl cytosine
149411-91-6

N-benzyloxycarbonyl cytosine

N-((N-<sup>4</sup>-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine
144564-94-3

N-((N-4-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: K2CO3 / dimethylformamide
2: aq. NaOH / 0.5 h
3: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, DCC / dimethylformamide; CH2Cl2 / 1.) 0 deg C, 2 h, 2.) r.t., 1 h
4: 69 percent / 1 M aq. LiOH / tetrahydrofuran / 0.25 h / 0 °C
With lithium hydroxide; sodium hydroxide; potassium carbonate; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
Multi-step reaction with 4 steps
1: K2CO3 / dimethylformamide / Ambient temperature
2: aq. NaOH
3: DCC, DhbtOH / dimethylformamide; CH2Cl2 / 0 °C
4: LiOH / tetrahydrofuran; H2O / 0 °C
With lithium hydroxide; sodium hydroxide; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

144564-94-3 Upstream products

  • 938175-07-6
    938175-07-6

    ethyl N-((N-4-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycinate

  • 501-53-1
    501-53-1

    benzyl chloroformate

  • 149411-91-6
    149411-91-6

    N-benzyloxycarbonyl cytosine

  • 144564-95-4
    144564-95-4

    [N4-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid

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    {[2-(2-{(2-amino-ethyl)-[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester

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