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pd_meltingpoint:210 °C
Appearance:Cream solid
Purity:99%
InChI:InChI=1/C7H9NOS.ClH/c9-7-3-5-4-8-2-1-6(5)10-7;/h3,6,8H,1-2,4H2;1H
The field of invention relates to a nove...
The invention provides a preparation met...
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The present invention provides an improv...
![5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine](/upload/2025/4/c45b964c-ebd2-4c07-8b01-ad118f85d648.png)
5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine
![5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride](/upload/2025/4/d95fb4f8-0738-4a20-a178-7bc8eb9a4cdf.png)
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water; acetone;
at 25 - 50 ℃;
for 1h;
|
99% |
|
With
hydrogenchloride;
In
ethanol;
at 45 ℃;
Solvent;
Inert atmosphere;
|
76% |
|
With
hydrogenchloride; water;
In
acetone;
at 56 ℃;
for 3h;
|
|
|
With
hydrogenchloride; water;
In
acetone;
at 25 - 30 ℃;
for 3h;
|
|
|
With
hydrogenchloride;
In
acetone;
|
|
|
With
hydrogenchloride;
In
water; acetone;
at 55 - 60 ℃;
for 3h;
|
|
|
With
hydrogenchloride;
In
acetone;
at 25 - 30 ℃;
for 4.5h;
Reflux;
|
![N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine](/upload/2025/4/fbf39685-0aec-4b46-a326-9b3491e20edd.png)
N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride
| Conditions | Yield |
|---|---|
|
N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;
With
N,N,N,N,-tetramethylethylenediamine; n-hexyllithium;
In
toluene;
at 0 ℃;
Large scale;
With
boric acid tributyl ester;
In
toluene;
at 0 ℃;
for 1h;
Further stages;
Large scale;
|
86.1% |
|
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
1.2: 1 h / 0 - 15 °C / Inert atmosphere
1.3: 2 h / 0 - 30 °C
2.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C
With
hydrogenchloride; n-butyllithium; water;
In
tetrahydrofuran; acetone;
|
|
|
Multi-step reaction with 2 steps
1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C
1.2: -5 - 10 °C
2.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C
With
hydrogenchloride; n-butyllithium;
In
tetrahydrofuran; hexane; water; acetone; toluene;
|
|
|
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
1.2: 1 h / 0 - 15 °C
1.3: 1.75 h / 0 - 30 °C / Reflux
2.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux
With
hydrogenchloride; n-butyllithium;
In
tetrahydrofuran; acetone;
|
5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
[2-(2-thyenyl)ethyl]amine
prasugel
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
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