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1693758-51-8

  • Product Name:IPI-549
  • Molecular Formula:C30H24N8O2
  • Molecular Weight:528.573
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Product Details

Purity:99%

Reputable factory supply IPI-549 1693758-51-8 in stock with high standard

  • Molecular Formula:C30H24N8O2
  • Molecular Weight:528.573
  • PKA:10.81±0.46(Predicted) 
  • Density:1.37±0.1 g/cm3(Predicted) 

1693758-51-8 Relevant articles

SOLID FORMS OF ISOQUINOLINONE DERIVATIVES, PROCESS OF MAKING, COMPOSITIONS COMPRISING, AND METHODS OF USING THE SAME

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Paragraph 00997; 00998; 00999; 001000; 001100-001108, (2017/04/11)

Solid forms of chemical compounds that m...

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

Evans, Catherine A.,Liu, Tao,Lescarbeau, André,Nair, Somarajan J.,Grenier, Louis,Pradeilles, Johan A.,Glenadel, Quentin,Tibbitts, Thomas,Rowley, Ann M.,Dinitto, Jonathan P.,Brophy, Erin E.,O'Hearn, Erin L.,Ali, Janid A.,Winkler, David G.,Goldstein, Stanley I.,O'Hearn, Patrick,Martin, Christian M.,Hoyt, Jennifer G.,Soglia, John R.,Cheung, Culver,Pink, Melissa M.,Proctor, Jennifer L.,Palombella, Vito J.,Tremblay, Martin R.,Castro, Alfredo C.

, p. 862 - 867 (2016/10/06)

Optimization of isoquinolinone PI3K inhi...

HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF PI3K-GAMMA MEDIATED DISORDERS

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, (2015/11/10)

Compounds and pharmaceutical composition...

HETEROCYCLIC COMPOUNDS AND USES THEREOF

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, (2015/04/22)

Compounds and pharmaceutical composition...

1693758-51-8 Process route

C<sub>23</sub>H<sub>20</sub>N<sub>4</sub>O

C23H20N4O

2,5-dioxopyrrolidin-1-yl-2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate

2,5-dioxopyrrolidin-1-yl-2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate

(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
1693758-51-8

(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;
85%
2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid
1394003-86-1

2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

C<sub>23</sub>H<sub>20</sub>N<sub>4</sub>O

C23H20N4O

(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
1693758-51-8

(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Conditions
Conditions Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 30 ℃; for 16h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
70%

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