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pd_meltingpoint:186～187℃
Purity:99%
InChI:InChI=1/C6H4F3NO2S/c1-2-10-4(6(7,8)9)3(13-2)5(11)12/h1H3,(H,11,12)
A series of novel thiazole acrylonitrile...
The invention belongs to the technical f...
The invention discloses a method of prep...
The invention relates to an optimization...
thioacetamide
ethyl 4,4,4-trifluoroacetoacetate
2-methyl-4-trifluoromethylthiazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
|
thioacetamide; ethyl 4,4,4-trifluoroacetoacetate;
In
acetonitrile;
at 30 ℃;
for 2.5h;
Large scale;
With
tri-n-propylamine;
In
acetonitrile;
at 30 - 40 ℃;
for 4h;
Reagent/catalyst;
Further stages;
Large scale;
|
90.8% |
ethyl 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylate
2-methyl-4-trifluoromethylthiazole-5-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
|
|
|
With
potassium hydroxide;
|
|
|
With
sodium hydroxide;
In
ethyl acetate;
at 40 ℃;
for 1h;
|
21.5 g |
|
With
sodium hydroxide;
In
ethanol; water;
for 3h;
Reflux;
|
ethyl 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylate
ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate
thioacetamide
ethyl 4,4,4-trifluoroacetoacetate
2-methyl-4-trifluoromethylthiazol-5-carboxylic acid (3',4',5'-trifluorobiphenyl-2-yl)amide
thifluzamide
N-(4'-chloro-3',5-difluorobiphenyl-2-yl)-2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
N-[5-(3,4-dichlorophenyl)-4-pyrimidinyl]-2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
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