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pd_meltingpoint:239 °C
Purity:99%
ABSTRACT The present invention provides ...
A novel synthesis of the anti-inflammato...
PCT No. PCT/IB97/01603 Sec. 371 Date Jul...
4-isocyanato-1,2,3,5,6, 7-hexahydro-s-indacene
4-(1-Hydroxy-1-methyl-ethyl)-furan-2-sulfonamide
MCC950
| Conditions | Yield |
|---|---|
|
4-(1-Hydroxy-1-methyl-ethyl)-furan-2-sulfonamide;
With
sodium methylate;
In
methanol;
4-isocyanato-1,2,3,5,6, 7-hexahydro-s-indacene;
at 20 ℃;
Reflux;
|
63% |
1,2,3,5,6,7-hexahydro-s-indacen-4-yl-amine
MCC950
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1.1: 80 g / Et3N / tetrahydrofuran / 4 h / Heating
2.1: MeONa / tetrahydrofuran
2.2: 4.9 g / tetrahydrofuran / 4 h / Heating
3.1: 8.33 g / aq. HCl
With
hydrogenchloride; sodium methylate; triethylamine;
In
tetrahydrofuran;
|
|
|
Multi-step reaction with 3 steps
1.1: dimethylaminopyridine / acetonitrile / 0.09 h / 20 °C
1.2: acetonitrile / 0.52 h / 20 °C
2.1: MeONa / tetrahydrofuran
2.2: 4.9 g / tetrahydrofuran / 4 h / Heating
3.1: 8.33 g / aq. HCl
With
hydrogenchloride; dmap; sodium methylate;
In
tetrahydrofuran; acetonitrile;
|
|
|
Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 3 h / 70 °C
2.1: sodium methylate / methanol
2.2: 20 °C / Reflux
With
sodium methylate; triethylamine;
In
tetrahydrofuran; methanol;
|
INDANE
3,5,6,7-tetrahydro-2H-s-indacen-1-one
3-chloro-1-(2,3-dihydro-1H-inden-5-yl)propan-1-one
1,2,3,5,6,7-hexahydro-s-indacen-4-yl-amine
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