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Purity:99%
Several 3-acylindoles with high affinity...
The present invention provides novel com...
4,4,4-trifluorobutyl methanesulfonate
(1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
![(2,2,3,3-tetramethylcyclopropyl)[1-(4,4,4-trifluorobutyl)-1H-indol-3-yl]methanone](/upload/2025/4/cce7fc7a-62fe-4bfd-a918-8f92eccb4c23.png)
(2,2,3,3-tetramethylcyclopropyl)[1-(4,4,4-trifluorobutyl)-1H-indol-3-yl]methanone
| Conditions | Yield |
|---|---|
|
(1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
4,4,4-trifluorobutyl methanesulfonate;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 45 ℃;
|
0.19 g |
2,2,3,3-tetramethylcyclopropane-1-carboxylic acid
(2,2,3,3-tetramethylcyclopropyl)[1-(4,4,4-trifluorobutyl)-1H-indol-3-yl]methanone
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1.1: thionyl chloride / 2 h / Reflux
2.1: ethylmagnesium bromide / tetrahydrofuran; dichloromethane / 21 °C
2.2: 0.5 h
2.3: 6 h / 21 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
3.2: 0 - 45 °C
With
thionyl chloride; ethylmagnesium bromide; sodium hydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
|
4,4,4-trifluorobutyl methanesulfonate
(1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
2,2,3,3-tetramethylcyclopropane-1-carboxylic acid
2,2,3,3-tetramethylcyclopropanecarbonyl chloride
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