What is the Iron Chelator, Dp44mT?

Iron Chelator, Dp44mT is , while it's Molecular Formula is C14H15N5S. Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand.

What is the CAS number for Iron Chelator, Dp44mT?

The CAS number of Iron Chelator, Dp44mT is 152095-12-0.

What is Iron Chelator, Dp44mT (152095-12-0) used for?

Dp44mT (152095-12-0) is a metal chelator with potent antitumor activity.1,2?It displayed an average IC50?of 30 nM over 28 cancer cell lines (IC50?range was 5 nM to 400 nM).2?Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50?= 12 nM for both lines.2?The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage.3,4?It also inhibited T-cell activation and prevented CD25 up-regulation?via?a copper-dependent mechanism.5?Dp44mT has recently been shown to effectively inhibit c-Met though metalloprotease-mediated cleavage and lysosomal degradation.6

What is the Iron Chelator, Dp44mT?

Iron Chelator, Dp44mT is , while it's Molecular Formula is C14H15N5S. Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand.

What is the CAS number for Iron Chelator, Dp44mT?

The CAS number of Iron Chelator, Dp44mT is 152095-12-0.

What is Iron Chelator, Dp44mT (152095-12-0) used for?

Dp44mT (152095-12-0) is a metal chelator with potent antitumor activity.1,2?It displayed an average IC50?of 30 nM over 28 cancer cell lines (IC50?range was 5 nM to 400 nM).2?Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50?= 12 nM for both lines.2?The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage.3,4?It also inhibited T-cell activation and prevented CD25 up-regulation?via?a copper-dependent mechanism.5?Dp44mT has recently been shown to effectively inhibit c-Met though metalloprotease-mediated cleavage and lysosomal degradation.6

Product classification

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152095-12-0

Product Name:Dp44mT
Molecular Formula:C14H15N5S
Molecular Weight:285.36700

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Product Details

Purity:99%

Quality Manufacturer Supply High Purity 99% Dp44mT 152095-12-0 with Reasonable Price

Molecular Formula:C14H15N5S
Molecular Weight:285.36700
PSA：92.54000
LogP:2.07640

152095-12-0 Relevant articles

Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity

Richardson, Des R.,Sharpe, Philip C.,Lovejoy, David B.,Senaratne, Dakshita,Kalinowski, Danuta S.,Islam, Mohammad,Bernhardt, Paul V.

, p. 6510 - 6521 (2006)

There has been much interest in the deve...

Analysis of the interaction of Dp44mT with human serum albumin and calf thymus DNA using molecular docking and spectroscopic techniques

Xu, Zhongjie,Liu, Youxun,Zhou, Sufeng,Fu, Yun,Li, Changzheng

, (2016)

Di-2-pyridylketone-4,4,-dimethyl-3-thios...

Semicarbazide derivatives and pharmaceutical compositions and uses thereof

-

Paragraph 0169-0171, (2020/05/11)

The invention relates to a selenosemicar...

Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety

Mrozek-Wilczkiewicz, Anna,Malarz, Katarzyna,Rejmund, Marta,Polanski, Jaroslaw,Musiol, Robert

, p. 180 - 194 (2019/03/27)

Thiosemicarbazones (TSC) are a subclass ...

A copper metal complex and its and human serum albumin complex and their synthetic method and application

-

Paragraph 0033; 0034; 0035; 0036; 0037; 0051-0052; 0054-0055, (2017/08/26)

The invention discloses a copper metal c...

Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores

Akladios, Fady N.,Andrew, Scott D.,Parkinson, Christopher J.

, p. 157 - 170 (2016/02/14)

Zinc is the second most abundant transit...

152095-12-0 Process route

: 19437-26-4
2,2'-dipyridyl ketone

: 6926-58-5
4,4-dimethylthiosemicarbazide

: 152095-12-0
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone

Conditions

Conditions	Yield
With acetic acid; In ethanol; water; for 2h; Heating;	87%
With acetic acid; In ethanol; Reflux;	70%
With acetic acid; In ethanol; Reflux;
In ethanol;
In methanol; at 35 - 50 ℃; for 48.25h; Solvent; Temperature; Reflux;
With acetic acid; In ethanol; at 83 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

: 152095-12-0
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone

Conditions

Conditions	Yield

152095-12-0 Upstream products

19437-26-4
2,2'-dipyridyl ketone
6926-58-5
4,4-dimethylthiosemicarbazide

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