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65340-70-7

  • Product Name:6-bromo-4-chloroquinoline
  • Molecular Formula:C9H5BrClN
  • Molecular Weight:242.502
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Product Details

pd_meltingpoint:110-112℃

Purity:99%

Reliable Quality 6-bromo-4-chloroquinoline 65340-70-7 Hot Sale with Chinese Manufacturer

  • Molecular Formula:C9H5BrClN
  • Molecular Weight:242.502
  • Vapor Pressure:0.001mmHg at 25°C 
  • Melting Point:110-112℃ 
  • Refractive Index:1.68 
  • Boiling Point:314.584 °C at 760 mmHg 
  • PKA:2.76±0.16(Predicted) 
  • Flash Point:144.056 °C 
  • PSA：12.89000 
  • Density:1.673 g/cm3 
  • LogP:3.65070 

6-BROMO-4-CHLOROQUINOLINE(Cas 65340-70-7) Usage

InChI:InChI=1/C9H5BrClN/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-5H

65340-70-7 Relevant articles

QUINOLINE-BASED COMPOUNDS AND METHODS OF INHIBITING CDK8/19

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Paragraph 0108; 0117-0119, (2020/03/09)

Disclosed herein are quinoline-based com...

6-bromo-4-chloroquinoline preparation method

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Paragraph 0026; 0027; 0036; 0037; 0045; 0046; 0056; 0057, (2017/03/28)

The invention discloses a 6-bromo-4-chlo...

PI3 kinase modulators and methods of use thereof, and use thereof

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Paragraph 0276; 0323; 0324, (2016/10/07)

The invention belongs to the field of me...

Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof

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Page/Page column 366, (2016/04/26)

The present invention provides for a met...

65340-70-7 Process route

6-bromoquinolin-4-ol
145369-94-4

6-bromoquinolin-4-ol

6-bromo-4-chloroquinoline
65340-70-7

6-bromo-4-chloroquinoline

Conditions
Conditions Yield
With trichlorophosphate; for 6h; Heating / reflux;
98.5%
With trichlorophosphate; for 2h; Reflux;
93%
With trichlorophosphate; for 1.5h; Reflux;
93%
With trichlorophosphate; In N,N-dimethyl-formamide; at 120 ℃; for 5h;
84%
6-bromoquinolin-4-ol; With trichlorophosphate; Heating / reflux;
With water;
84%
With trichlorophosphate; In toluene; at 115 ℃; for 4h;
32%
With trichlorophosphate; In toluene; at 115 ℃; for 4h;
32%
With trichlorophosphate; at 135 ℃;
 
With trichlorophosphate; for 1.5h; Reflux;
 
With trichlorophosphate; at 20 ℃; for 19h;
 
With trichlorophosphate; In N,N-dimethyl-formamide; for 6h; Reflux; Inert atmosphere;
 
With trichlorophosphate; for 24h; Reflux;
 
With trichlorophosphate; for 1.5h; Reflux;
 
With trichlorophosphate; for 1.5h; Reflux;
 
With trichlorophosphate; for 1.5h; Reflux;
 
6-bromo-3-quinolinecarboxylic acid-4-ol
145369-94-4,332366-57-1

6-bromo-3-quinolinecarboxylic acid-4-ol

6-bromo-4-chloroquinoline
65340-70-7

6-bromo-4-chloroquinoline

Conditions
Conditions Yield
With trichlorophosphate; for 2h; Reflux;
99%
With phosphorus trichloride; In toluene; for 2h; Concentration; Reflux;
92.6%
With thionyl chloride; N,N-dimethyl-formamide; for 3h; Heating / reflux;
85%
With trichlorophosphate; In N,N-dimethyl-formamide; for 2h; Reflux;
70%

65340-70-7 Upstream products

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    145369-94-4

    6-bromoquinolin-4-ol

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    N-(2-acetyl-4-bromophenyl)acetamide

  • 68-12-2
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    N,N-dimethyl-formamide

  • 98948-95-9
    98948-95-9

    6-bromo-4-hydroxyquinoline-3-carboxylic acid

65340-70-7 Downstream products

  • 878276-92-7
    878276-92-7

    4-chloro-6-(4-chlorophenyl)quinoline

  • 500127-41-3
    500127-41-3

    4-chloro-6-(4-methoxyphenyl)quinoline

  • 474707-23-8
    474707-23-8

    tert-butyl 4-(6-bromoquinolin-4-yl)piperazine-1-carboxylate

  • 676256-25-0
    676256-25-0

    4-chloroquinoline-6-carbaldehyde

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