What is the N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide?

N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide is , while it's Molecular Formula is C26H22N2O2. Salermide is an inhibitor of SIRT1, SIRT2, and HDAC.

What is the CAS number for N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide?

The CAS number of N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide is 1105698-15-4.

What is N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide (1105698-15-4) used for?

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~20 μM) by reactivating proapototic genes that are repressed by SIRT1.

What is the N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide?

N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide is , while it's Molecular Formula is C26H22N2O2. Salermide is an inhibitor of SIRT1, SIRT2, and HDAC.

What is the CAS number for N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide?

The CAS number of N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide is 1105698-15-4.

What is N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide (1105698-15-4) used for?

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~20 μM) by reactivating proapototic genes that are repressed by SIRT1.

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1105698-15-4

Product Name:Salermide
Molecular Formula:C26H22N2O2
Molecular Weight:394.473

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Product Details

Purity:99%

Reliable Quality Salermide 1105698-15-4 Hot Sale with Chinese Manufacturer

Molecular Formula:C26H22N2O2
Molecular Weight:394.473
Boiling Point:666.7±50.0 °C(Predicted)
PKA:7.90±0.50(Predicted)
PSA：61.69000
Density:1.16±0.1 g/cm3(Predicted)
LogP:6.11120

1105698-15-4 Relevant articles

Discovery of salermide-related sirtuin inhibitors: Binding mode studies and antiproliferative effects in cancer cells including cancer stem cells

Rotili, Dante,Tarantino, Domenico,Nebbioso, Angela,Paolini, Chantal,Huidobro, Covadonga,Lara, Ester,Mellini, Paolo,Lenoci, Alessia,Pezzi, Riccardo,Botta, Giorgia,Lahtela-Kakkonen, Maija,Poso, Antti,Steinkühler, Christian,Gallinari, Paola,De Maria, Ruggero,Fraga, Mario,Esteller, Manel,Altucci, Lucia,Mai, Antonello

, p. 10937 - 10947 (2013/02/25)

Chemical changes performed on 1a (sirtin...

1105698-15-4 Process route

: 1105698-16-5
(R/S)-N-(3-aminophenyl)-2-phenylpropanamide

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: 1105698-15-4
salermide

Conditions

Conditions	Yield
With acetic acid; In ethanol; benzene; Reflux;	84%

: 492-37-5,2328-24-7
hydratropic acid

: 108-45-2,64554-26-3,76583-20-5
m-phenylenediamine

: 1105698-15-4
salermide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: acetic acid / ethanol; benzene / Reflux With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; In ethanol; benzene;

1105698-15-4 Upstream products

1105698-16-5
(R/S)-N-(3-aminophenyl)-2-phenylpropanamide
708-06-5
2-hydroxynaphthalene-1-carbaldehyde
492-37-5
hydratropic acid
108-45-2
m-phenylenediamine

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