What is the Fruquintinib|HMPL-013?

Fruquintinib|HMPL-013 is , while it's Molecular Formula is C 21 H 19 N 3 O 5 . Fruquintinib is a multi-targeted tyrosine kinase inhibitor, a third-line regimen involved in the treatment of advanced non-small cell lung cancer in humans. Fruquintinib is a potent, highly selective and orally active inhibitor of VEGFR1, 2, 3 tyrosine kinases.

What is the CAS number for Fruquintinib|HMPL-013?

The CAS number of Fruquintinib|HMPL-013 is 1194506-26-7.

What is Fruquintinib|HMPL-013 (1194506-26-7) used for?

Fruquintinib is a VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively). It also inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases. Fruquintinib inhibits VEGF-A-induced proliferation of human umbilical vein endothelial cells (HUVECs) and VEGF-C-induced proliferation of human lymphatic endothelial cells (HLECs; IC50s = 1.7 and 4.2 nM, respectively). It decreases tube formation by HUVECs by 74 and 94% when used at concentrations of 30 and 300 nM, respectively. Fruquintinib (0.5-20 mg/kg per day for 21 days) reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models.

What is the Fruquintinib|HMPL-013?

Fruquintinib|HMPL-013 is , while it's Molecular Formula is C 21 H 19 N 3 O 5 . Fruquintinib is a multi-targeted tyrosine kinase inhibitor, a third-line regimen involved in the treatment of advanced non-small cell lung cancer in humans. Fruquintinib is a potent, highly selective and orally active inhibitor of VEGFR1, 2, 3 tyrosine kinases.

What is the CAS number for Fruquintinib|HMPL-013?

The CAS number of Fruquintinib|HMPL-013 is 1194506-26-7.

What is Fruquintinib|HMPL-013 (1194506-26-7) used for?

Fruquintinib is a VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively). It also inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases. Fruquintinib inhibits VEGF-A-induced proliferation of human umbilical vein endothelial cells (HUVECs) and VEGF-C-induced proliferation of human lymphatic endothelial cells (HLECs; IC50s = 1.7 and 4.2 nM, respectively). It decreases tube formation by HUVECs by 74 and 94% when used at concentrations of 30 and 300 nM, respectively. Fruquintinib (0.5-20 mg/kg per day for 21 days) reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models.

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1194506-26-7

Product Name:Fruquintinib
Molecular Weight:393.399

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Product Details

Purity:99%

Factory Sells Best Quality Fruquintinib 1194506-26-7 with steady supply

Molecular Formula:C₂₁H₁₉N₃O₅
Molecular Weight:393.399
Boiling Point:600.5±55.0 °C(Predicted)
PKA:14.35±0.46(Predicted)
Density:1.302±0.06 g/cm3(Predicted)

1194506-26-7 Relevant articles

Synthetic method of VEGFR inhibitor furoquitinib and benzofuran intermediate thereof

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Paragraph 0063; 0095-0099, (2021/05/01)

The invention discloses a synthetic meth...

QUINAZOLINE DERIVATIVES

-

Page/Page column 5-6, (2009/12/04)

Quinazoline derivatives of the following...

1194506-26-7 Process route

: 638217-08-0
6-hydroxy-2-methylbenzofuran-3-carboxylic acid methylamide

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 1194506-26-7
6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

Conditions

Conditions	Yield
In acetone; at 60 ℃; for 12h; Inert atmosphere;	89%
With potassium carbonate; In acetonitrile; for 10h; Reflux;	85%

: 150-19-6
O-methylresorcine

: 1194506-26-7
6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 30 °C 2.1: triethylamine / dichloromethane / 2 h / 30 °C 3.1: dibromobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 4.1: potassium tert-butylate / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 5.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere 6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Inert atmosphere 6.2: 2 h / 0 - 25 °C / Inert atmosphere 7.1: acetone / 12 h / 60 °C / Inert atmosphere With dibromobis(triphenylphosphine)nickel(II); N-Bromosuccinimide; potassium tert-butylate; boron tribromide; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Yield

Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 30 °C

2.1: triethylamine / dichloromethane / 2 h / 30 °C

3.1: dibromobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere

5.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Inert atmosphere

6.2: 2 h / 0 - 25 °C / Inert atmosphere

7.1: acetone / 12 h / 60 °C / Inert atmosphere

With dibromobis(triphenylphosphine)nickel(II); N-Bromosuccinimide; potassium tert-butylate; boron tribromide; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

1194506-26-7 Upstream products

638217-08-0
6-hydroxy-2-methylbenzofuran-3-carboxylic acid methylamide
13790-39-1
6,7-dimethoxy-4-chloroquinazoline
150-19-6
O-methylresorcine
63604-94-4
2-bromo-5-methoxyphenol

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