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254740-64-2

  • Product Name:Sparsentan
  • Molecular Formula:C32H40N4O5S
  • Molecular Weight:592.75
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Product Details

pd_meltingpoint:148 °C(Solv: isopropanol (67-63-0); water (7732-18-5))

Purity:99%

Factory Sells Best Quality Sparsentan 254740-64-2 with stock We supply high quality Sparsentan (RE-021) (CAS 254740-64-2), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Sparsentan (RE-021) ?

Sparsentan (RE-021) is , while it's Molecular Formula is C32H40N4O5S. RE 201 is used an Endothelin A receptor antagonist used in the treatment of hypertension.

What is the CAS number for Sparsentan (RE-021) ?

The CAS number of Sparsentan (RE-021) is 254740-64-2.

More information of Sparsentan (RE-021) 254740-64-2 are:

Synonyms

 Sparsentan (RE-021);Sparsentan-d5 (RE-021-d5);RE 201;[1,1'-Biphenyl]-2-sulfonamide, 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-;Sparsentan;4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

CAS Number

 254740-64-2

Molecular Formula

 C32H40N4O5S

Molecular Weight

 592.75

Density

 1.28±0.1 g/cm3(Predicted)

Melting Point

 148 °C(Solv: isopropanol (67-63-0); water (7732-18-5))

Boiling Point

 744.4±70.0 °C(Predicted)

PSA

 122.48000

LogP

 7.06670

Pka

 7.06±0.50(Predicted)

What is Sparsentan (RE-021) (254740-64-2) used for?

Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.

Articles related to Sparsentan (RE-021):

Article

Source

A BIPHENYLSULFONAMIDE ENDOTHELIN AND ANGIOTENSIN II RECEPTOR ANTAGONIST TO TREAT GLOMERULOSCLEROSIS

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Paragraph 0175; 0155; 0157, (2017/07/06)

Dual angiotensin II and endothelin A receptor antagonists: Synthesis of 2′-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics

Murugesan, Natesan,Gu, Zhengxiang,Fadnis, Leena,Tellew, John E.,Baska, Rose Ann F.,Yang, Yifan,Beyer, Sophie M.,Monshizadegan, Hossain,Dickinson, Kenneth E.,Valentine, Maria T.,Humphreys, W. Griffith,Lan, Shih-Jung,Ewing, William R.,Carlson, Kenneth E.,Kowala, Mark C.,Zahler, Robert,Macor, John E.

, p. 171 - 179 (2007/10/03)

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