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Purity:99%
The present invention discloses a pyrimi...
The present invention discloses a 2-amin...
The present invention discloses a pipera...
The hazard assessment of a telescoped Mi...
![6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole](/upload/2025/4/db8f10b6-ee91-443d-9853-f3ff699ccbcf.png)
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
2,4-dichloro-5-fluoropyrimidine
![6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole](/upload/2025/4/fbd02f01-8ee8-46b4-9fb5-ad46ca46f0e3.png)
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
| Conditions | Yield |
|---|---|
|
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 0 - 5 ℃;
Inert atmosphere;
2,4-dichloro-5-fluoropyrimidine;
With
iron(III)-acetylacetonate;
In
tetrahydrofuran;
at 55 - 60 ℃;
Inert atmosphere;
|
76% |
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
diethylene glycol dimethyl ether;
at 80 ℃;
for 4h;
Inert atmosphere;
|
60% |
2,4-dichloro-5-fluoropyrimidine
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
| Conditions | Yield |
|---|---|
|
With
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate;
In
1,4-dioxane; water;
at 80 ℃;
for 5h;
Inert atmosphere;
|
78.5% |
4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole
2,4-dichloro-5-fluoropyrimidine
N-isopropylacetamide
N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine
LY2835219
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