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632-85-9

  • Product Name:Wogonin
  • Molecular Formula:C16H12O5
  • Molecular Weight:284.268
  • Appearance:yellow crystal
Inquiry

Product Details

pd_meltingpoint:203-206 °C

Appearance:yellow crystal

Purity:99%

Reputable manufacturer supply Wogonin 632-85-9 in stock with high standard

  • Molecular Formula:C16H12O5
  • Molecular Weight:284.268
  • Appearance/Colour:yellow crystal 
  • Vapor Pressure:2.21E-11mmHg at 25°C 
  • Melting Point:203-206 °C 
  • Refractive Index:1.668 
  • Boiling Point:518.8 °C at 760 mmHg 
  • PKA:6.83±0.40(Predicted) 
  • Flash Point:198.3 °C 
  • PSA：79.90000 
  • Density:1.42 g/cm3 
  • LogP:2.87980 

Wogonin(Cas 632-85-9) Usage

Biochem/physiol Actions

Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.

Definition

ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.

General Description

Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots.

InChI:InChI=1/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3

632-85-9 Relevant articles

A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin

Li, Tinghan,Weng, Tianwei,Wang, Jubo,Wei, Zhihui,Zhao, Lu,Li, Zhiyu

, p. 171 - 176 (2017/02/26)

A scalable and practical route to wogoni...

Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation

Yamashita, Yasunobu,Biard, Alan,Hanaya, Kengo,Shoji, Mitsuru,Sugai, Takeshi

, p. 1279 - 1284 (2017/06/27)

Wogonin and astringin were synthesized f...

Preparation method and intermediates of flavonoids

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Paragraph 0241; 0243-0245, (2017/11/16)

The invention discloses a preparation me...

Preparation method of flavonoids

-

Paragraph 0241-0245, (2017/11/16)

The invention discloses a preparation me...

632-85-9 Process route

(E)-3-Phenyl-1-(2,4,6-trihydroxy-3-methoxy-phenyl)-propenone
571168-66-6

(E)-3-Phenyl-1-(2,4,6-trihydroxy-3-methoxy-phenyl)-propenone

oroxylin A
480-11-5

oroxylin A

wogonin
632-85-9

wogonin

Conditions
Conditions Yield
With iodine; dimethyl sulfoxide; Heating;
46%
24%
oroxylin A
480-11-5

oroxylin A

wogonin
632-85-9

wogonin

Conditions
Conditions Yield
24%
46%

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    (E)-3-Phenyl-1-(2,4,6-trihydroxy-3-methoxy-phenyl)-propenone

  • 4443-09-8
    4443-09-8

    norwogonin

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    74-88-4

    methyl iodide

632-85-9 Downstream products

  • 95480-80-1
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    5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl acetate

  • 23050-38-6
    23050-38-6

    5,7,8-trimethoxy-2-phenyl-chromen-4-one

  • 4443-09-8
    4443-09-8

    norwogonin

  • 1356855-04-3
    1356855-04-3

    C16H12O5*C42H70O35

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