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Purity:99%
Auristatins are a class of ultrapotent m...
The present invention relates to an anti...
The present invention relates to a metho...
The present invention relates to an anti...
![tert-butyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methyl heptanoate](/upload/2025/4/7a0262ac-78a5-42d4-8711-2844c2ee6634.png)
tert-butyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methyl heptanoate
tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
ethanol; water;
at 20 ℃;
for 18h;
|
87% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 18h;
under 760.051 Torr;
|
82% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 18h;
under 760.051 Torr;
|
82% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 18h;
under 760.051 Torr;
|
82% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol; water;
at 20 ℃;
for 18h;
Inert atmosphere;
|
82% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 18h;
|
82% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol; water;
at 20 ℃;
for 18h;
|
82% |
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
ethanol;
at 20 ℃;
for 18h;
|
82% |
tert-Butyl (3R,4S,5S)-3-methoxy-4-
tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
methanol;
for 3h;
under 2327.23 Torr;
Inert atmosphere;
|
92% |
|
tert-Butyl (3R,4S,5S)-3-methoxy-4-
With
hydrogenchloride;
In
1,4-dioxane;
at -78 ℃;
for 0.25h;
|
90% |
tert-Butyl (3S,4S,5S)-3-methoxy-4-
acetic acid tert-butyl ester
N-Cbz-L-Isoleucine
tert-Butyl (3S,4S,5S)-3-hydroxy-4-
tert-butyl (3R,4S,5S)-4-[(2S)-2-[[(benzyloxy)carbonyl]amino]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoate
dolastatin 10
(3R,4S,5S)-tert-butyl 4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoate
methyl (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate
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