What is the 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester?

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester is , while it's Molecular Formula is C17H17ClN2O5. SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid.

What is the CAS number for 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester?

The CAS number of 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester is 305834-79-1.

What is 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester (305834-79-1) used for?

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. For example, both Thr308 and Ser473 on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 μg/ml). SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling. SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.

What is the 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester?

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester is , while it's Molecular Formula is C17H17ClN2O5. SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid.

What is the CAS number for 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester?

The CAS number of 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester is 305834-79-1.

What is 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester (305834-79-1) used for?

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. For example, both Thr308 and Ser473 on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 μg/ml). SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling. SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.

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305834-79-1

Product Name:SC79
Molecular Formula:C17H17ClN2O5
Molecular Weight:364.78

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Product Details

Purity:99%

Purity 99% Min SC79 305834-79-1 Spot Supply with Safe Transportation

Molecular Formula:C17H17ClN2O5
Molecular Weight:364.78
Boiling Point:524.8±50.0 °C(Predicted)
PKA:3.03±0.40(Predicted)
PSA：111.64000
Density:1.340±0.06 g/cm3(Predicted)
LogP:2.95258

305834-79-1 Relevant articles

Reactions of salicylaldehydes with alkyl cyanoacetates on the surface of solid catalysts: Syntheses of 4H-chromene derivatives

Yu,Aramini,Germann,Huang

, p. 6993 - 6996 (2000)

Substituted 4H-chromene derivatives are ...

Aegle marmelos in heterocyclization: Greener, highly efficient, one-pot three-component protocol for the synthesis of highly functionalized 4 H -benzochromenes and 4 H -chromenes

Shinde, Sachin,Damate, Shashikant,Morbale, Smita,Patil, Megha,Patil, Suresh S.

, p. 7315 - 7328 (2017/02/05)

A facile, one-pot three-component protoc...

One-pot synthesis of 4H-chromene and dihydropyrano[3, 2-c]chromene derivatives in hydroalcoholic media

Ghorbani-Vaghei, Ramin,Toghraei-Semiromi, Zahra,Karimi-Nami, Rahman

experimental part, p. 905 - 909 (2012/01/06)

4ff-Chromenes and dihydropyrano[3, 2-c]c...

Potassium exchanged layered zirconium phosphate as catalyst in the preparation of 4H-chromenes

Curini, Massimo,Epifano, Francesco,Chimichi, Stefano,Montanari, Francesca,Nocchetti, Morena,Rosati, Ornelio

, p. 3497 - 3499 (2007/10/03)

Substituted 4H-chromenes were easily pre...

305834-79-1 Process route

: 105-56-6
ethyl 2-cyanoacetate

: 635-93-8
5-chlorosalicyclaldehyde

: 305834-79-1
SC79

Conditions

Conditions	Yield
potassium-exchanged zirconium hydrogen phosphate; at 40 ℃; for 4h;	94%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; In ethanol; water; at 20 ℃; for 4.5h;	92%
With water extract of soft ash obtained from rind of dry Aegle marmelos (bael) fruits; In ethanol; water; at 20 ℃; for 0.25h; Green chemistry;	91%
With 3 A molecular sieve; In ethanol; at 20 ℃; for 14h;	70.7%

305834-79-1 Upstream products

105-56-6
ethyl 2-cyanoacetate
635-93-8
5-chlorosalicyclaldehyde

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