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287383-59-9

  • Product Name:Scriptaid
  • Molecular Formula:C18H18N2O4
  • Molecular Weight:326.352
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Product Details

pd_meltingpoint:160-161℃

Purity:99%

Top Quality Scriptaid 287383-59-9 Hot Sell In Stock

  • Molecular Formula:C18H18N2O4
  • Molecular Weight:326.352
  • Melting Point:160-161℃ 
  • Refractive Index:1.646 
  • PSA：88.40000 
  • Density:1.338 g/cm3 
  • LogP:2.40940 

SCRIPTAID(Cas 287383-59-9) Usage

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

General Description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

InChI:InChI=1/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

287383-59-9 Relevant articles

A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Fleming, Cassandra L.,Ashton, Trent D.,Nowell, Cameron,Devlin, Mark,Natoli, Anthony,Schreuders, Jeannette,Pfeffer, Frederick M.

supporting information, p. 7827 - 7830 (2015/05/13)

Fluorescence microscopy studies using 4-...

FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT

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Page/Page column, (2015/06/16)

The present invention provides a highly ...

A convenient synthesis of the new histone deacetylase inhibitor scriptaid

Gerova, Mariana S.,Petrov, Ognyan I.

, p. 76 - 79 (2014/03/21)

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287383-59-9 Process route

C<sub>21</sub>H<sub>21</sub>NO<sub>6</sub>

C21H21NO6

scriptaid
287383-59-9

scriptaid

Conditions
Conditions Yield
With hydroxylamine; In methanol; at 20 ℃; for 1h;
71%
6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)hexanamide

6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-((tetrahydro-2H-pyran-2-yl)oxy)hexanamide

scriptaid
287383-59-9

scriptaid

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In water; isopropyl alcohol; at 21 ℃; for 16h;
57%

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