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pd_meltingpoint:85-87°C(lit.)
Appearance:Off-white crystal
Purity:99%
InChI:InChI=1/C6H5BClFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,10-11H
The invention relates to the field of li...
The present invention relates to quinazo...
Trimethyl borate
2-chloro-5-bromofluorobenzene
3-fluoro-4-chlorophenylboronic acid
| Conditions | Yield |
|---|---|
|
2-chloro-5-bromofluorobenzene;
With
magnesium;
In
tetrahydrofuran;
at 20 - 30 ℃;
for 1h;
Trimethyl borate;
In
tetrahydrofuran;
at 0 - 10 ℃;
for 2h;
|
86% |
2-chloro-5-bromofluorobenzene
3-fluoro-4-chlorophenylboronic acid
| Conditions | Yield |
|---|---|
|
2-chloro-5-bromofluorobenzene;
With
n-butyllithium; Triisopropyl borate;
In
tetrahydrofuran; hexanes;
at -100 - 20 ℃;
for 18.25h;
With
hydrogenchloride;
In
tetrahydrofuran; hexanes; water;
at 20 ℃;
|
2-chloro-5-bromofluorobenzene
Trimethyl borate
4'-chloro-5,3'-difluoro-biphenyl-2-yl-amine
6-(4-chloro-3-fluorophenyl)-1-methyl-N-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
3-(4'-chloro-3'-fluorobiphenyl-4-yl)-1-[(2S)-2-(4-phenyl-1H-imidazol-2-yl)pyrrolidin-1-yl]propan-1-one
C24H24ClFN4O2S
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