1060804-53-6

  • Product Name:2-chloro-5-hydroxyisonicotinaldehyde
  • Molecular Formula:C6H4ClNO2
  • Molecular Weight:157.55400
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Product Details

Purity:99%

Quality Factory Sells Top Purity 99% 2-chloro-5-hydroxyisonicotinaldehyde 1060804-53-6 with Safe Delivery

  • Molecular Formula:C6H4ClNO2
  • Molecular Weight:157.55400
  • Boiling Point:353.3±37.0 °C(Predicted) 
  • PKA:6.71±0.10(Predicted) 
  • PSA:50.19000 
  • Density:1.504±0.06 g/cm3(Predicted) 
  • LogP:1.25310 

1060804-53-6 Relevant articles

HETEROCYCLICS AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR

-

, (2019/06/05)

This disclosure relates to heterocyclics...

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Zak, Mark,Yuen, Po-Wai,Liu, Xiongcai,Patel, Snahel,Sampath, Deepak,Oeh, Jason,Liederer, Bianca M.,Wang, Weiru,O'Brien, Thomas,Xiao, Yang,Skelton, Nicholas,Hua, Rongbao,Sodhi, Jasleen,Wang, Yunli,Zhang, Lei,Zhao, Guiling,Zheng, Xiaozhang,Ho, Yen-Ching,Bair, Kenneth W.,Dragovich, Peter S.

, p. 8345 - 8368 (2016/10/03)

NAMPT inhibitors may show potential as t...

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

-

, (2013/09/12)

Disclosed are certain amido-benzyl sulfo...

1060804-53-6 Process route

2-chloro-5-(methoxymethoxy)pyridine-4-carbaldehyde
1282516-32-8

2-chloro-5-(methoxymethoxy)pyridine-4-carbaldehyde

2-chloro-5-hydroxypyridine-4-carbaldehyde
1060804-53-6

2-chloro-5-hydroxypyridine-4-carbaldehyde

Conditions
Conditions Yield
With hydrogenchloride; In tetrahydrofuran; water; at 20 - 60 ℃; for 19h;
63%
With hydrogenchloride; In tetrahydrofuran; water; at 60 ℃; for 1h;
6 g
With hydrogenchloride; In tetrahydrofuran; water; at 60 ℃; for 1h;
6.01 g
2-chloro-5-(methoxymethoxy)pyridine
877133-56-7

2-chloro-5-(methoxymethoxy)pyridine

2-chloro-5-hydroxypyridine-4-carbaldehyde
1060804-53-6

2-chloro-5-hydroxypyridine-4-carbaldehyde

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -80 - -70 °C / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 60 °C
With hydrogenchloride; tert.-butyl lithium; In tetrahydrofuran; water; pentane;
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 60 °C
With hydrogenchloride; tert.-butyl lithium; In tetrahydrofuran; water; pentane;
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 2 h / -60 °C
1.2: 2 h / 20 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 19 h / 20 - 60 °C
With hydrogenchloride; n-butyllithium; In tetrahydrofuran; water;

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