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1199796-29-6

  • Product Name:INT-777，
  • Molecular Weight:450.659
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Product Details

pd_meltingpoint:150-152℃

Purity:99%

Top Quality Chinese Manufacturer supply 1199796-29-6 INT-777，

  • Molecular Formula:C27H46O5
  • Molecular Weight:450.659
  • Melting Point:150-152℃ 
  • Boiling Point:602.8±55.0 °C(Predicted) 
  • PKA:4.80±0.21(Predicted) 
  • Density:1.128±0.06 g/cm3(Predicted) 

1199796-29-6 Relevant articles

TGR5 MODULATORS AND METHODS OF USE THEROF

-

Page/Page column 28, (2010/06/22)

The invention relates to compounds of Fo...

Discovery of 6α-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity

Pellicciari, Roberto,Gioiello, Antimo,Macchiarulo, Antonio,Thomas, Charles,Rosatelli, Emiliano,Natalini, Benedetto,Sardella, Roccaldo,Pruzanski, Mark,Roda, Aldo,Pastorini, Elisabetta,Schoonjans, Kristina,Auwerx, Johan

supporting information; experimental part, p. 7958 - 7961 (2010/08/22)

In the framework of the design and devel...

1199796-29-6 Process route

methyl 3α,7α,12α-trimethoxymethyloxy-6α-ethyl-5β-cholan-24-oate
1227639-47-5

methyl 3α,7α,12α-trimethoxymethyloxy-6α-ethyl-5β-cholan-24-oate

methyl iodide
74-88-4

methyl iodide

INT-777
1199796-29-6

INT-777

Conditions
Conditions Yield
methyl 3α,7α,12α-trimethoxymethyloxy-6α-ethyl-5β-cholan-24-oate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;
methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
41%
C<sub>28</sub>H<sub>48</sub>O<sub>5</sub>

C28H48O5

INT-777
1199796-29-6

INT-777

6α-ethyl-23(S)-methyl-3α,7α,12α trihydroxy-5β-cholan-24-oic acid
1198786-98-9

6α-ethyl-23(S)-methyl-3α,7α,12α trihydroxy-5β-cholan-24-oic acid

Conditions
Conditions Yield
With sodium hydroxide; In methanol; at 45 ℃; for 24h; Inert atmosphere;
53%
30%

1199796-29-6 Upstream products

  • 1227639-47-5
    1227639-47-5

    methyl 3α,7α,12α-trimethoxymethyloxy-6α-ethyl-5β-cholan-24-oate

  • 74-88-4
    74-88-4

    methyl iodide

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