What is the BOC-PNA-G(Z)-OH?

BOC-PNA-G(Z)-OH is , while it's Molecular Formula is C24H29 N7 O8. Used in Nucleic Acid Research: BOC-PNA-G(Z)-OH is used as a research tool for studying the interactions between PNA and nucleic acids, such as DNA and RNA, due to its high binding affinity and specificity. Used in Diagnostics: In the diagnostics industry, BOC-PNA-G(Z)-OH is used as a molecular probe for detecting specific DNA or RNA sequences, contributing to the development of sensitive and accurate diagnostic assays. Used in Therapeutics: BOC-PNA-G(Z)-OH is utilized as a building block in the development of antisense oligonucleotides, which have potential therapeutic applications in modulating gene expression and treating various diseases by targeting specific nucleic acid sequences. Used in Drug Development: In the pharmaceutical industry, BOC-PNA-G(Z)-OH is used as a component in the design of drugs that target specific genetic sequences, potentially leading to more targeted and effective treatments for a range of conditions.

What is the CAS number for BOC-PNA-G(Z)-OH?

The CAS number of BOC-PNA-G(Z)-OH is 169287-77-8.

What is BOC-PNA-G(Z)-OH (169287-77-8) used for?

BOC-PNA-G(Z)-OH is a chemical compound that features a peptide nucleic acid (PNA) monomer with a BOC protecting group on the N-terminus, a guanine base (G), and a Z protecting group on the C-terminus. This PNA monomer is a synthetic nucleic acid mimic designed to bind to complementary DNA or RNA sequences with high affinity and specificity. The BOC protecting group temporarily blocks the reactive amine on the N-terminus, while the Z protecting group ensures stability at the C-terminus. BOC-PNA-G(Z)-OH is instrumental in nucleic acid research, diagnostics, and therapeutics, particularly for the development of antisense oligonucleotides and molecular probes for detecting specific DNA or RNA sequences.

What is the BOC-PNA-G(Z)-OH?

BOC-PNA-G(Z)-OH is , while it's Molecular Formula is C24H29 N7 O8. Used in Nucleic Acid Research: BOC-PNA-G(Z)-OH is used as a research tool for studying the interactions between PNA and nucleic acids, such as DNA and RNA, due to its high binding affinity and specificity. Used in Diagnostics: In the diagnostics industry, BOC-PNA-G(Z)-OH is used as a molecular probe for detecting specific DNA or RNA sequences, contributing to the development of sensitive and accurate diagnostic assays. Used in Therapeutics: BOC-PNA-G(Z)-OH is utilized as a building block in the development of antisense oligonucleotides, which have potential therapeutic applications in modulating gene expression and treating various diseases by targeting specific nucleic acid sequences. Used in Drug Development: In the pharmaceutical industry, BOC-PNA-G(Z)-OH is used as a component in the design of drugs that target specific genetic sequences, potentially leading to more targeted and effective treatments for a range of conditions.

What is the CAS number for BOC-PNA-G(Z)-OH?

The CAS number of BOC-PNA-G(Z)-OH is 169287-77-8.

What is BOC-PNA-G(Z)-OH (169287-77-8) used for?

BOC-PNA-G(Z)-OH is a chemical compound that features a peptide nucleic acid (PNA) monomer with a BOC protecting group on the N-terminus, a guanine base (G), and a Z protecting group on the C-terminus. This PNA monomer is a synthetic nucleic acid mimic designed to bind to complementary DNA or RNA sequences with high affinity and specificity. The BOC protecting group temporarily blocks the reactive amine on the N-terminus, while the Z protecting group ensures stability at the C-terminus. BOC-PNA-G(Z)-OH is instrumental in nucleic acid research, diagnostics, and therapeutics, particularly for the development of antisense oligonucleotides and molecular probes for detecting specific DNA or RNA sequences.

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169287-77-8

Product Name:Boc-PNA-G(Z)-OH
Molecular Formula:C24H29 N7 O8
Molecular Weight:543.53

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Product Details

Purity:99%

Offer Chemical Raw Material Boc-PNA-G(Z)-OH 169287-77-8 In Stock

Molecular Formula:C24H29 N7 O8
Molecular Weight:543.53
PKA:3.32±0.10(Predicted)
PSA：197.84000
Density:1.44±0.1 g/cm3(Predicted)
LogP:1.77010

169287-77-8 Relevant articles

A convergent strategy for the modification of peptide nucleic acids: Novel mismatch-specific PNA-hybridization probes

Seitz, Oliver,Bergmann, Frank,Heindl, Dieter

, p. 2203 - 2206 (1999)

Coupling of nonnatural nucleobases to th...

Convergent strategies for the attachment of fluorescing reporter groups to peptide nucleic acids in solution and on solid phase

Seitz, Oliver,Koehler, Olaf

, p. 3911 - 3925 (2007/10/03)

The site-selective conjugation of peptid...

169287-77-8 Process route

: 141743-15-9
2-((((9H-fluoren-9-yl)methoxy)carbonyl)(2-((tert-butoxycarbonyl)amino)ethyl)amino)acetic acid

: 169287-77-8
Boc-PNA(G^Z)-OH

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 92 percent / Bu₄NBr; aq. NaHCO₃ / CH₂Cl₂ / 14 h 2: 94 percent / Zn; AcOH / 1.5 h With tetrabutylammomium bromide; sodium hydrogencarbonate; acetic acid; zinc; In dichloromethane;
Multi-step reaction with 3 steps 1: 92 percent / NaHCO₃; Bu₄NBr / CH₂Cl₂ 2: 94 percent / Zn; AcOH 3: 61 percent With tetrabutylammomium bromide; sodium hydrogencarbonate; acetic acid; zinc; In dichloromethane; 1: Alkylation / 2: Reduction;

: 169287-69-8
2-[2-(benzyloxycarbonyl)amino-6-oxo-1,6-dihydro-9H-purin-9-yl]acetic acid

: 230618-02-7
(E)-17-[N-[2-(tert-Butyloxycarbonylamino)ethyl]-N-fluorenylmethyloxycarbonylglycinyloxy]-4,7,10,13-tetraoxa-15-heptadecenoic acid

: 169287-77-8
Boc-PNA(G^Z)-OH

Conditions

Conditions	Yield
Multistep reaction;	61%
Multistep reaction.;	61%

169287-77-8 Upstream products

169287-69-8
2-[2-(benzyloxycarbonyl)amino-6-oxo-1,6-dihydro-9H-purin-9-yl]acetic acid
230618-02-7
(E)-17-[N-[2-(tert-Butyloxycarbonylamino)ethyl]-N-fluorenylmethyloxycarbonylglycinyloxy]-4,7,10,13-tetraoxa-15-heptadecenoic acid
90495-99-1
N-(2-tert-butoxycarbonylaminoethyl)aminoacetic acid
72648-80-7
ethyl 2-[2-(tert-butoxycarbonylamino)ethyl-[3-[[4-(4,5-difluoro-2-methylsulfanyl-phenyl)phenoxy]methyl]benzoyl]amino]acetate

169287-77-8 Downstream products

230618-01-6
C₆₃H₇₀N₂₀O₁₉
1009310-79-5
C₅₈H₇₈N₁₆O₁₄
1009310-78-4
C₅₆H₇₄N₁₆O₁₄
249287-96-5
N-[2-(N-dithiasuccinoyl)aminoethyl]-N-[[2-N-(benzyloxycarbonyl)guanin-9-yl]acetyl]glycine

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