What is the Aloxistatin?

Aloxistatin is , while it's Molecular Formula is C 17 H 30 N 2 O 5 . E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.

What is the CAS number for Aloxistatin?

The CAS number of Aloxistatin is 88321-09-9.

What is Aloxistatin (88321-09-9) used for?

E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 and prodrug form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and -L. E-64d (20-200 μM) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. It inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM. E-46d also inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 spike glycoprotein into Vero cells, an effect that is reduced by expression of the serine protease TMPRSS2.InChI:InChI=1/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12?,13-,14-/m0/s1

What is the Aloxistatin?

Aloxistatin is , while it's Molecular Formula is C 17 H 30 N 2 O 5 . E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.

What is the CAS number for Aloxistatin?

The CAS number of Aloxistatin is 88321-09-9.

What is Aloxistatin (88321-09-9) used for?

E-64d is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases and has diverse biological activities. It is a synthetic analog of E-64 and prodrug form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, -K, -B, -H, and -L. E-64d (20-200 μM) induces cell cycle arrest at the G2/M phase in A431 human epidermoid carcinoma cells. It inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM. E-46d also inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 spike glycoprotein into Vero cells, an effect that is reduced by expression of the serine protease TMPRSS2.InChI:InChI=1/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12?,13-,14-/m0/s1

Product classification

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：+86 15965530500
Website：http://www.shandonghangyu.com/
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

88321-09-9

Product Name:EST
Molecular Formula:C17H30 N2 O5
Molecular Weight:342.436

Inquiry

Product Details

pd_meltingpoint:126.2°C

Purity:99%

Chinese Manufacturer Supply EST 88321-09-9 On Stock with Competitive Price

Molecular Formula:C₁₇H₃₀N₂O₅
Molecular Weight:342.436
Vapor Pressure:1.2E-11mmHg at 25°C
Melting Point:126.2°C
Refractive Index:1.5800 (estimate)
Boiling Point:538°C at 760 mmHg
Flash Point:279.2°C
PSA：97.03000
Density:1.102g/cm³
LogP:1.79190

Aloxistatin(Cas 88321-09-9) Usage

Biochem/physiol Actions	E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B, calpains 1 and 2. E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI) and Alzheimer′s disease (AD). It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.
Safety Profile	Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Definition	ChEBI: An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylb tyl)-L-leucinamide.

InChI:InChI=1/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12?,13-,14-/m0/s1

88321-09-9 Relevant articles

COMPOSITIONS AND METHODS FOR SYNTHESIZING (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO-3-METHYLBUTANE ETHYL ESTER

-

Paragraph 0056; 0057; 0059; 0072; 0073, (2017/07/06)

In alternative embodiments the invention...

Design, synthesis, and screen of cathepsin K inhibitors

Yu, Ying-Ying,Sun, Wei,Dong, Lei,Liu, Hai-Dong,Jiang, Dan,Xiao, Jun-Hai,Yang, Xiao-Hong,Li, Song

, p. 715 - 718 (2013/07/26)

We synthesized a series of epoxysuccinic...

Stereoselective synthesis of the epoxysuccinyl peptide E-64c

Lygo, Barry,Gardiner, Stuart D.,To, Daniel C. M.

, p. 2063 - 2066 (2008/02/05)

A highly diastereoselective PTC epoxidat...

A new synthesis of peptidyl epoxysuccinates for probing cysteine protease-inhibitor P3/S3 binding interactions

Roush, William R.,Hernandez, Alejandro Alvarez,Zepeda, Gerardo

, p. 1500 - 1504 (2007/10/03)

A new synthesis of peptidyl epoxysuccina...

88321-09-9 Process route

: 63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7
ethyl (2S,3S)-2,3-epoxysuccinate

: 84851-37-6,167693-86-9
(S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride

: 88321-09-9
aloxistatin

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 0 - 20 ℃; for 3h; Reagent/catalyst; Inert atmosphere;	100%

: (S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-aminium 4-methylbenzenesulfonate

: 63734-73-6,66647-16-3,68521-71-1,89886-73-7,93061-20-2,149884-11-7
ethyl (2S,3S)-2,3-epoxysuccinate

: 88321-09-9
aloxistatin

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 0 - 20 ℃; for 4h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;	99%

88321-09-9 Upstream products

84851-37-6
N¹-isoamylleucinamide
100464-19-5
2-ethyl 3-(4-nitrophenyl) (2S,3S)-oxirane-2,3-dicarboxylate
84851-37-6
(S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride
107-85-7
1-amino-3-methylbutane

88321-09-9 Downstream products

140660-53-3
(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester
140660-55-5
5-<3-<2-ethyl>-1H-indolyl> (+)-(2S,3S)-3-<<(S)-3-methyl-1-<(3-methylbutyl)carbamoyl>butyl>carbamoyl>-2-oxiranecarboxylate
140660-60-2
N-<2-<5-(benzyloxy)-1H-indol-3-yl>ethyl> (2S,3S)-3-<<(S)-3-methyl-1-<(3-methylbutyl)carbamoyl>butyl>carbamoyl>-2-oxiranecarboxamide
140660-56-6
(R)-2-({(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxiranecarbonyl}-amino)-3-phenyl-propionic acid methyl ester

Relevant Products

JORO SPIDER TOXIN JSTX-3
CAS：112163-33-4
cis-13-Docosenoamide
CAS：112-84-5
Parylene N
CAS：1633-22-3
Bexagliflozin
CAS：1118567-05-7