13647-35-3

Quality products make an important contribution to long-term revenue and profitability. China cas 13647-35-3 factory wholesale Trilostane at affordable price

1.What is the Trilostane ?

Trilostane can inhibit 3β-dehydrogenase in the synthesis of corticosteroids, and decrease the synthesis of cortisol and aldosterone. It also can be used in the treatment of Cushing's syndrome (hypercortisolism) and primary aldosteronism. But the efficacy to treat Cushing's syndrome (hypercortisolism) is not as metyrapone. This product also has a significant role in lowering blood testosterone levels, which may be related with that its synthesis is inhibited.

Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.

2.What is the CAS number for Trilostane ?

The CAS number of Trilostane is 13647-35-3.

More information of Trilostane 13647-35-3 are:

3.What are another words for Trilostane ?

Synonyms for Trilostane 13647-35-3:Desopan;Modrastane;Modrefen;Modrenal;5-alpha-Androstane-2-alpha-carbonitrile, 4-alpha,5-epoxy-17-;Vetoryl;Win 24540;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-Epoxy-17-hydroxy-3-;

4.What is the molecular formula of Trilostane?

The chemical formula of  Trilostane is C₂₀H₂₇NO₃ which containing 20 Carbon atoms,27 Hydrogen atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of  Trilostane is 329.439.

5.What is Trilostane (13647-35-3) used for?

3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively. Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.

InChI:InChI=1/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1

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6.Buy Trilostane with the best price .

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