What is the Estetrol?

Estetrol is , while it's Molecular Formula is C18H24O4. A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.

What is the CAS number for Estetrol?

The CAS number of Estetrol is 15183-37-6.

What is Estetrol (15183-37-6) used for?

Estetrol, also known as E4, is an estrogen steroid hormone that is exclusively produced by the fetal liver from estradiol and estriol during pregnancy. It is characterized by its off-white solid appearance and has a unique binding affinity to estrogen receptors (ERs), with a 4-fold higher affinity for ERα over ERβ. Estetrol exhibits estrogenic effects in most tissues expressing ERs, such as bone, brain, vagina, and endometrium. Interestingly, in breast tumors, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.InChI:InChI=1/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12?,13-,14?,15?,16?,17+,18+/m1/s1

What is the Estetrol?

Estetrol is , while it's Molecular Formula is C18H24O4. A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.

What is the CAS number for Estetrol?

The CAS number of Estetrol is 15183-37-6.

What is Estetrol (15183-37-6) used for?

Estetrol, also known as E4, is an estrogen steroid hormone that is exclusively produced by the fetal liver from estradiol and estriol during pregnancy. It is characterized by its off-white solid appearance and has a unique binding affinity to estrogen receptors (ERs), with a 4-fold higher affinity for ERα over ERβ. Estetrol exhibits estrogenic effects in most tissues expressing ERs, such as bone, brain, vagina, and endometrium. Interestingly, in breast tumors, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.InChI:InChI=1/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12?,13-,14?,15?,16?,17+,18+/m1/s1

Product classification

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15183-37-6

Product Name:Estetrol
Molecular Formula:C₁₈H₂₄O₄
Molecular Weight:304.386

Inquiry

Product Details

pd_meltingpoint:233-236°C

Purity:99%

Manufacturer Supply Best Quality Estetrol 15183-37-6 with Efficient Transportation

Molecular Formula:C18H24O4
Molecular Weight:304.386
Melting Point:233-236°C
Refractive Index:1.65
Boiling Point:491.9 °C at 760 mmHg
PKA:10.22±0.70(Predicted)
Flash Point:231.7 °C
PSA：80.92000
Density:1.343 g/cm³
LogP:1.55080

Estetrol(Cas 15183-37-6) Usage

InChI:InChI=1/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12?,13-,14?,15?,16?,17+,18+/m1/s1

15183-37-6 Relevant articles

Synthesis of 15α-hydroxyestrogen 15-N-acetylglucosaminides

Suzuki, Emako,Namba, Susumu,Kurihara, Hiroyuki,Goto, Junichi,Matsuki, Yasuhiko,Nambara, Toshio

, p. 277 - 284 (1995)

The synthesis of 15-N-acetylglucosaminid...

INDUSTRIAL PROCESS FOR THE PREPARATION OF HIGH PURITY ESTETROL

-

Page/Page column 19, (2021/03/13)

The invention relates to the preparation...

PROCESS FOR PREPARING (15ΑLPHA,16ΑLPHA,17ΒETA)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) AND INTERMEDIATES OF SAID PROCESS

-

Page/Page column 14-15, (2021/04/02)

The present invention relates to a proce...

PROCESS FOR THE PREPARATION OF ESTETROL

-

, (2015/04/15)

The invention relates to a process for o...

Process for the preparation of estetrol

-

Page/Page column 20, (2011/11/12)

The present invention relates to a proce...

15183-37-6 Process route

: 690996-23-7
17-acetyl estetrol

: 15183-37-6,30653-26-0
15α-hydroxyestriol

Conditions

Conditions	Yield
With potassium carbonate; In methanol; at 20 ℃; for 4h;	92.5%
17-acetyl estetrol; With methanol; potassium carbonate; at 20 ℃; for 4h; With hydrogenchloride; In chloroform; water;	92.5%

: (15α,16α,17β)-3-hydroxyestra-1,3,5(10)-triene-15,16,17-triyl triacetate

: 15183-37-6,30653-26-0
15α-hydroxyestriol

Conditions

Conditions	Yield
With potassium carbonate; In methanol; at 20 - 25 ℃; for 3h; Inert atmosphere;	97.22%
With potassium carbonate; at 25 ℃; for 4h;	13 g

15183-37-6 Upstream products

16127-99-4
3,17β-diacetoxyestra-1,3,5(10)-triene-15α,16α-diol
16127-98-3
15-dehydroestradiol 3,17-diacetate
690996-23-7
17-acetyl estetrol
53-16-7
Estrone

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