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Purity:99%
Anaplastic lymphoma kinase (ALK) targete...
The present invention relates to a N2,N4...
The present invention provides a pyrimid...
The invention belongs to the field of me...
1-(3-methoxy-4 nitrophenyl)piperidin-4-one
dimethyl amine
1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine
Conditions | Yield |
---|---|
1-(3-methoxy-4 nitrophenyl)piperidin-4-one; dimethyl amine;
With
sodium tris(acetoxy)borohydride; acetic acid;
In
tetrahydrofuran; 1,2-dichloro-ethane;
With
sodium hydrogencarbonate;
In
water;
pH=> 7;
|
88% |
With
formic acid; trimethyl orthoformate;
In
tetrahydrofuran;
at 70 ℃;
for 7h;
|
75.04% |
4-fluoro-2-methoxy-1-nitrobenzene
N,N-dimethylpiperidine-4-amine hydrochloride
1-(3-methoxy-4-nitrophenyl)-N,N-dimethylpiperidine-4-amine
Conditions | Yield |
---|---|
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
|
80% |
1-(3-methoxy-4 nitrophenyl)piperidin-4-one
dimethyl amine
dimethyl-piperidin-4-yl-amine
4-fluoro-2-methoxy-1-nitrobenzene
1-(4-amino-3-methoxyphenyl)-N,N-dimethylpiperidine-4-amine
(2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl )amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
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