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pd_meltingpoint:160-163 °C(lit.)
Appearance:Light yellow powder
Purity:99%
|
Synthesis Reference(s) |
Journal of Medicinal Chemistry, 20, p. 965, 1977 DOI: 10.1021/jm00217a023 |
InChI:InChI=1/C5H5NO4/c1-9-5(8)3-2-4(7)6-10-3/h2H,1H3,(H,6,7)
The insect GABA receptor (GABAR), which ...
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N-hydroxyurea
dimethyl acetylenedicarboxylate
methyl 3-hydroxy-5-isoxazolecarboxylate
| Conditions | Yield |
|---|---|
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol;
at 0 - 10 ℃;
|
72% |
|
With
triethylamine;
In
methanol;
for 1h;
Ambient temperature;
|
60% |
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol;
at 0 - 20 ℃;
for 12.5h;
|
42% |
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol;
at 0 - 20 ℃;
Inert atmosphere;
|
39.8% |
|
N-hydroxyurea; dimethyl acetylenedicarboxylate;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol;
at 0 ℃;
With
hydrogenchloride;
In
methanol; water;
|
N-hydroxyurea
dimethyl acetylenedicarboxylate
3-oxo-2,3-dihydro-isoxazole-5-carboxylic acid methyl ester
| Conditions | Yield |
|---|---|
|
With
1,5-Diazabicyclo[5.4.0]undec-5-ene;
In
methanol;
at 0 ℃;
Cooling;
|
40% |
methanol
3-hydroxy-5-isoxazole hydroxamic acid
dimethyl 2-bromofumarate
N-hydroxyurea
3-Hydroxyisoxazole-5-(N-isopropyl)-carboxamide
3-Hydroxyisoxazole-5-(N-methyl)-carboxamide
3-methoxyisoxazole-5-carboxylic acid methyl ester
2-Methyl-3-oxo-2,3-dihydro-isoxazole-5-carboxylic acid methyl ester
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