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Purity:99%
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benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate
sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
| Conditions | Yield |
|---|---|
|
With
sodium hydrogensulfite;
In
ethanol; water; ethyl acetate;
at 50 ℃;
for 3h;
|
73% |
|
With
water; sodium hydrogensulfite;
In
ethanol; ethyl acetate;
at 40 ℃;
for 2h;
|
methyl (L)-leucinate hydrochloride
sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 7 steps
1: 1,4-dioxane
2: triethylamine
3: lithium hydroxide; water / tetrahydrofuran
4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
5: lithium borohydride / tetrahydrofuran
6: Dess-Martin periodane / dichloromethane
7: sodium hydrogensulfite; water / ethanol; ethyl acetate / 2 h / 40 °C
With
lithium borohydride; water; benzotriazol-1-ol; Dess-Martin periodane; sodium hydrogensulfite; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction with 7 steps
1.1: triethylamine / 1,4-dioxane / Inert atmosphere; Reflux
2.1: triethylamine / acetonitrile / 2 h / Reflux
3.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
4.2: 12 h
5.1: lithium borohydride / tetrahydrofuran / 20 °C
6.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
7.1: sodium hydrogensulfite / water; ethanol; ethyl acetate / 3 h / 50 °C
With
lithium borohydride; benzotriazol-1-ol; Dess-Martin periodane; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
6.1: |Dess-Martin Oxidation;
|
benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate
methyl (L)-leucinate hydrochloride
N-benzyloxycarbonyl-L-leucine methyl ester
Z-Leu-OH
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