What is the Tetradecylthioacetic acid?

Tetradecylthioacetic acid is white cyrstalline solid, while it's Molecular Formula is C16H32O2S. white cyrstalline solid TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.

What is the CAS number for Tetradecylthioacetic acid?

The CAS number of Tetradecylthioacetic acid is 2921-20-2.

What is Tetradecylthioacetic acid (2921-20-2) used for?

Tetradecylthioacetic acid (TTA), a representative member of the 3-thia family, has the chemical structure of palmitic acid (C16) in which a sulfur atom is located between the 2 and 3-carbon atoms (COOH-CH2-S-(CH2)13-CH3). TTA is a novel hypolipidemic drug which has been shown to combine several effects of w-3 PUFAs, such as EPA, and structurally unrelated peroxisome proliferators, such as phenylacetate and fibrates. From this perspective we wanted to investigate if TTA shares the antitumor activity found for these functionally related compounds, and furthermore to study the metabolic effects of TTA in cancer cells in relation to the effects found in hepatocytes.InChI:InChI=1/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)

What is the Tetradecylthioacetic acid?

Tetradecylthioacetic acid is white cyrstalline solid, while it's Molecular Formula is C16H32O2S. white cyrstalline solid TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.

What is the CAS number for Tetradecylthioacetic acid?

The CAS number of Tetradecylthioacetic acid is 2921-20-2.

What is Tetradecylthioacetic acid (2921-20-2) used for?

Tetradecylthioacetic acid (TTA), a representative member of the 3-thia family, has the chemical structure of palmitic acid (C16) in which a sulfur atom is located between the 2 and 3-carbon atoms (COOH-CH2-S-(CH2)13-CH3). TTA is a novel hypolipidemic drug which has been shown to combine several effects of w-3 PUFAs, such as EPA, and structurally unrelated peroxisome proliferators, such as phenylacetate and fibrates. From this perspective we wanted to investigate if TTA shares the antitumor activity found for these functionally related compounds, and furthermore to study the metabolic effects of TTA in cancer cells in relation to the effects found in hepatocytes.InChI:InChI=1/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)

Product classification

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：+86 15965530500
Website：http://www.shandonghangyu.com/
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

2921-20-2

Product Name:Tetradecylthioacetic acid
Molecular Formula:C₁₆H₃₂O₂S
Molecular Weight:288.495
Appearance:white cyrstalline solid

Inquiry

Product Details

pd_meltingpoint:65-73 °C

Appearance:white cyrstalline solid

Purity:99%

Excellent chemical plant bulk supply Tetradecylthioacetic acid 2921-20-2

Molecular Formula:C16H32O2S
Molecular Weight:288.495
Appearance/Colour:white cyrstalline solid
Vapor Pressure:1.32E-07mmHg at 25°C
Melting Point:65-73 °C
Refractive Index:1.481
Boiling Point:402.6 °C at 760 mmHg
PKA:3.85±0.10(Predicted)
Flash Point:197.3 °C
PSA：62.60000
Density:0.957 g/cm³
LogP:5.50530

Tetradecylthioacetic acid(Cas 2921-20-2) Usage

InChI:InChI=1/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)

2921-20-2 Relevant articles

Metal extracting agent containing sulfoxide group and preparation method thereof

-

Paragraph 0050; 0051; 0052, (2017/07/04)

The invention discloses a metal extracti...

The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism

Lund, Jenny,Stensrud, Camilla,Rajender,Bohov, Pavol,Thoresen, G. Hege,Berge, Rolf K.,Wright, Michael,Kamal, Ahmed,Rustan, Arild C.,Miller, Andrew D.,Skorve, Jon

, p. 1191 - 1203 (2016/03/01)

Thio-ether fatty acids (THEFAs), includi...

NATURAL LIPIDS CONTAINING NON-OXIDIZABLE FATTY ACIDS

-

Paragraph 00324-00328, (2016/02/18)

Provided herein is technology relating t...

Sulfur makes the difference: Synthesis and mesomorphic properties of novel thioether-functionalized imidazolium ionic liquid crystals

Mansueto, Markus,Kre?, Katharina Christina,Laschat, Sabine

, p. 6258 - 6264 (2015/03/30)

Novel thioether-linked imidazolium ionic...

2921-20-2 Process route

: 112-71-0
1-Bromotetradecane

: 68-11-1
mercaptoacetic acid

: 2921-20-2
tetradecylthioacetic Acid

Conditions

Conditions	Yield
1-Bromotetradecane; mercaptoacetic acid; With methanol; potassium hydroxide; at 20 ℃; With hydrogenchloride; In water;	94%
1-Bromotetradecane; mercaptoacetic acid; With potassium hydroxide; In methanol; at 20 ℃; With hydrogenchloride; In methanol; water; at 20 ℃;	94%
1-Bromotetradecane; mercaptoacetic acid; With potassium hydroxide; In methanol; at 20 ℃; With hydrogenchloride; water; In methanol; at 20 ℃;	94%
With potassium hydroxide; In methanol; at 20 ℃;	94%
1-Bromotetradecane; mercaptoacetic acid; With potassium hydroxide; In methanol; at 20 ℃; With hydrogenchloride; water; In methanol;	94%
With sodium hydroxide; In methanol; at 20 ℃; for 72h; Inert atmosphere;	91%
1-Bromotetradecane; mercaptoacetic acid; With sodium methylate; In methanol; at 20 ℃; for 48h; Acidic conditions;	82%
With sodium methylate; In methanol; diethyl ether; at 20 ℃; for 16h;	77%
With sodium hydroxide; In methanol; at 20 ℃; for 72h; Inert atmosphere;	75%
1-Bromotetradecane; mercaptoacetic acid; With potassium hydroxide; In methanol; at 20 ℃; for 24h; Inert atmosphere; With hydrogenchloride; In methanol; water;	62%
With methanol; sodium hydroxide; at 20 ℃; for 20.5h; Reflux; Large scale;	19.9 kg

: methyl 2-(tetradecylthio)acetate

: 2921-20-2
tetradecylthioacetic Acid

Conditions

Conditions	Yield
With lithium hydroxide; In ethanol; at 20 ℃; for 48h;	100%

2921-20-2 Upstream products

1120-36-1
1-tetradecene
68-11-1
mercaptoacetic acid
112-71-0
1-Bromotetradecane
2079-95-0
1-tetradecanethiol

2921-20-2 Downstream products

497263-42-0
2-tetradecylthioacetamidopropane-1,3-diol
733010-52-1
1,3-di(tert-butyloxycarbonylamino)-2-[(tetradecylthio)acetyloxy]-propane
2387-23-7
1,3-Dicyclohexylurea

Relevant Products

Prasugrel
CAS：115473-15-9
OXACILLIN SODIUM
CAS：1173-88-2
H-Tpi-OMe.HCl
CAS：83159-19-7
L-Spinacine(H-Spi-OH.HCl)
CAS：88980-06-7