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66104-23-2

  • Product Name:Pergolide mesylate
  • Molecular Formula:C19H26N2S.CH4O3S
  • Molecular Weight:410.602
  • Appearance:White to off-white solid
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Product Details

pd_meltingpoint:252-254 °C

Appearance:White to off-white solid

Purity:99%

Reputable manufacturer supply Pergolide mesylate 66104-23-2 in stock with high standard We supply high quality Pergolide mesylate salt (CAS 66104-23-2), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Pergolide mesylate salt ?

Pergolide mesylate salt is White to off-white solid, while it's Molecular Formula is CH4O3S*C19H26N2S. A dopaminergic agonist that also decrease plasma prolactin concentrations. An antiparkinsonian agent

What is the CAS number for Pergolide mesylate salt ?

The CAS number of Pergolide mesylate salt is 66104-23-2.

More information of Pergolide mesylate salt 66104-23-2 are:

Synonyms

 Ergoline,8-[(methylthio)methyl]-6-propyl-,(8a)-,monomethanesulfonate;Prestwick_652;Pergolide mesilate;MPE;Permax (TN);Pergolide mesylate [USAN];Ergoline, 8-((methylthio)methyl)-6-propyl-, (8beta)-;LY127809;Ergoline, 8-[ (methylthio)methyl]-6-propyl-, (8.beta.)-, monomethanesulfonate;Pergolida [INN-Spanish];Pergolide mesilate (JAN);Permax;Pergolide mesylate (USP);Ergoline, 8-beta-((methylthio)methyl)-6-propyl-, methanesulfonate (1:1);Pergolidum [INN-Latin];8-.beta.-[(Methylthio)methyl]-6-propylergoline methanesulfonate;8-beta-((Methylthio)methyl)-6-propylergoline monomethane sulfonate;Pergolide mesilate salt;

CAS Number

 66104-23-2

Molecular Formula

 CH4O3S*C19H26N2S

Molecular Weight

 410.602

Melting Point

 252-254 °C

Boiling Point

 491.3 °C at 760 mmHg

Flash Point

 250.9 °C

HS CODE

 2939690000

PSA

 107.08000

LogP

 4.79380

Pka

 pKa (66% DMF) 7.8(at 25℃)

What is Pergolide mesylate salt (66104-23-2) used for?

Pergolide is a potent dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors). It depresses dopaminergic firing in paralyzed rats (ED50 = <20 μg/kg), an effect that can be reversed by the dopamine D2-selective antagonist spiperone or the dopamine D1-selective antagonist SCH 23390 . Pergolide (0.025 and 0.05 mg/kg) increases the volume threshold for inducing bladder contraction in a cynomolgus monkey model of Parkinson''s disease induced by MPTP. It also reduces carrageenan-induced paw edema in adrenalectomized rats (ED50 = 0.4 mg/kg).

InChI:InChI=1/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1

Articles related to Pergolide mesylate salt:

Article

Source

Development of a practical high-yield industrial synthesis of pergolide mesylate

Cabri, Walter,Roletto, Jacopo,Olmo, Sara,Fonte, Piera,Ghetti, Paolo,Songia, Simonetta,Mapelli, Elio,Alpegiani, Marco,Paissoni, Paolo

, p. 198 - 202 (2012/12/22)

6-N-Propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds

-

, (2008/06/13)

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