What is the 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate?

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is , while it's Molecular Formula is C6H10N2O.CH4O3S. Used in Pharmaceutical Industry: 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is used as an active pharmaceutical ingredient for the treatment of insomnia. It is employed as a selective antagonist for orexin receptors, OX1R and OX2R, to regulate sleep-wake cycles and improve sleep quality. Used in Sleep Aid Medications: In the sleep aid medication industry, 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is used as a key component in insomnia treatments. It helps to increase total sleep time and reduce the time it takes for individuals to fall asleep, providing relief for those struggling with sleep disorders. Used in Research and Development: 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is also utilized in the research and development of new sleep medications and therapies. Its mechanism of action and selectivity for orexin receptors make it a valuable compound for studying sleep regulation and developing novel treatments for sleep disorders.

What is the CAS number for 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate?

The CAS number of 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is 709031-45-8.

What is 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate (709031-45-8) used for?

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate, commonly known as Suvorexant, is a pharmaceutical compound specifically designed for the treatment of insomnia. It functions by selectively blocking orexin receptors in the brain, which are integral to the regulation of sleep-wake cycles. As a potent and selective antagonist for both orexin receptor subtypes, OX1R and OX2R, Suvorexant effectively increases total sleep time and decreases the latency to sleep onset. The monomethanesulfonate salt form of Suvorexant is utilized in the pharmaceutical industry for the formulation of the medication, ensuring its efficacy and tolerability for patients with sleep disorders.

What is the 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate?

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is , while it's Molecular Formula is C6H10N2O.CH4O3S. Used in Pharmaceutical Industry: 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is used as an active pharmaceutical ingredient for the treatment of insomnia. It is employed as a selective antagonist for orexin receptors, OX1R and OX2R, to regulate sleep-wake cycles and improve sleep quality. Used in Sleep Aid Medications: In the sleep aid medication industry, 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is used as a key component in insomnia treatments. It helps to increase total sleep time and reduce the time it takes for individuals to fall asleep, providing relief for those struggling with sleep disorders. Used in Research and Development: 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is also utilized in the research and development of new sleep medications and therapies. Its mechanism of action and selectivity for orexin receptors make it a valuable compound for studying sleep regulation and developing novel treatments for sleep disorders.

What is the CAS number for 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate?

The CAS number of 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate is 709031-45-8.

What is 2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate (709031-45-8) used for?

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3S,5S)-,monomethanesulfonate, commonly known as Suvorexant, is a pharmaceutical compound specifically designed for the treatment of insomnia. It functions by selectively blocking orexin receptors in the brain, which are integral to the regulation of sleep-wake cycles. As a potent and selective antagonist for both orexin receptor subtypes, OX1R and OX2R, Suvorexant effectively increases total sleep time and decreases the latency to sleep onset. The monomethanesulfonate salt form of Suvorexant is utilized in the pharmaceutical industry for the formulation of the medication, ensuring its efficacy and tolerability for patients with sleep disorders.

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709031-45-8

Product Name:(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate
Molecular Formula:C6H10N2O.CH4O3S
Molecular Weight:222.265

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Product Details

Purity:99%

Factory Sells Best Quality (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate 709031-45-8 with steady supply

Molecular Formula:C6H10N2O.CH4O3S
Molecular Weight:222.265
Vapor Pressure:0-0Pa at 20-25℃
PSA：118.86000
Density:1.5g/cm3 at 20℃
LogP:1.28540

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709031-45-8 Process route

: 75-75-2,98527-29-8
methanesulfonic acid

: 361440-67-7
[1S-(1α,3β,5α)]-3-(aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid 1,1-dimethylethyl ester

: 709031-45-8
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methane sulphonic acid

Conditions

Conditions	Yield
In isopropyl alcohol; at 60 - 70 ℃; for 5h;	96.7%
In isopropyl alcohol; at 55 - 65 ℃; for 3.5h; Large scale reaction;	94%
In isopropyl alcohol; at 60 ℃;	80%

: 194594-23-5
5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 709031-45-8
(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methane sulphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: dmap; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine 2: water; lithium hydroxide / ethanol 3: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran 4: diethylzinc / 1,2-dimethoxyethane; dichloromethane / -30 - 20 °C 5: isopropyl alcohol / 60 °C With dmap; ammonia; water; diethylzinc; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; isopropyl alcohol; 4: \|Simmons-Smith Cyclopropanation;

Yield

Multi-step reaction with 5 steps

1: dmap; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine

2: water; lithium hydroxide / ethanol

3: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran

4: diethylzinc / 1,2-dimethoxyethane; dichloromethane / -30 - 20 °C

5: isopropyl alcohol / 60 °C

With dmap; ammonia; water; diethylzinc; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; isopropyl alcohol; 4: |Simmons-Smith Cyclopropanation;

709031-45-8 Upstream products

75-75-2
methanesulfonic acid
361440-67-7
[1S-(1α,3β,5α)]-3-(aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid 1,1-dimethylethyl ester
194594-23-5
5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester
144978-35-8
(S)-ethyl N-tert-butoxycarbonylpyroglutamate

709031-45-8 Downstream products

361442-01-5
tert-butyl [(1S)-2-[(1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.1³'⁷]dec-1-yl)-2-oxoethyl]carbamate
709031-43-6
3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester
1564265-93-5
saxagliptin
1564265-93-5
(R)-3-hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile

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