What is the 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE?

2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE is , while it's Molecular Formula is C15H15NO3S. This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2 .

What is the CAS number for 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE?

The CAS number of 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE is 221615-75-4.

What is 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE (221615-75-4) used for?

2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)ETHAN-1-ONE is a chemical compound that serves as an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2.InChI:InChI=1/C15H15NO3S/c1-11-3-6-13(10-16-11)15(17)9-12-4-7-14(8-5-12)20(2,18)19/h3-8,10H,9H2,1-2H3

What is the 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE?

2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE is , while it's Molecular Formula is C15H15NO3S. This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2 .

What is the CAS number for 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE?

The CAS number of 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE is 221615-75-4.

What is 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE (221615-75-4) used for?

2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)ETHAN-1-ONE is a chemical compound that serves as an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2.InChI:InChI=1/C15H15NO3S/c1-11-3-6-13(10-16-11)15(17)9-12-4-7-14(8-5-12)20(2,18)19/h3-8,10H,9H2,1-2H3

Product classification

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221615-75-4

Product Name:1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone
Molecular Formula:C₁₅H₁₅NO₃S
Molecular Weight:289.355

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Product Details

Purity:99%

Factory Sells Best Quality 1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone 221615-75-4 with steady supply

Molecular Formula:C15H15NO3S
Molecular Weight:289.355
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.573
Boiling Point:509.695 °C at 760 mmHg
PKA:3.75±0.10(Predicted)
Flash Point:262.054 °C
PSA：72.48000
Density:1.242 g/cm³
LogP:3.29970

2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE(Cas 221615-75-4) Usage

InChI:InChI=1/C15H15NO3S/c1-11-3-6-13(10-16-11)15(17)9-12-4-7-14(8-5-12)20(2,18)19/h3-8,10H,9H2,1-2H3

221615-75-4 Relevant articles

Etoricoxib purification and preparation method

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Paragraph 0065; 0136-0138; 0145-0147; 0152-0154; 0159-0161, (2019/04/17)

The invention relates to an etoricoxib p...

Continuous flow production process for etoricoxib intermediate

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Paragraph 0036; 0044; 0051-0054; 0062-0065, (2018/11/04)

The invention discloses a continuous flo...

Preparation of relying on tests the past intermediate 1 - (6 - methyl pyridine - 3 - yl) - 2 - [4 - (methylsulfonyl) phenyl] ethanone method

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Paragraph 0056-0057, (2017/08/25)

The invention provides a preparation met...

Method for preparing etoricoxib

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Paragraph 0046; 0047; 0048, (2017/08/02)

The invention discloses a method for pre...

221615-75-4 Process route

: 36357-38-7
1-(6-methyl-pyridin-3-yl)-ethanone

: 3466-32-8
4-bromoohenyl methyl sulfone

: 221615-75-4
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

Conditions

Conditions	Yield
With potassium phosphate; palladium(II) acetylacetonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 18h; Product distribution / selectivity; Inert atmosphere;	91%
With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; for 5h; Concentration; Inert atmosphere; Reflux;	75%
With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; for 4h; Concentration; Inert atmosphere; Reflux;	75%
With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; for 5h; Concentration; Inert atmosphere; Reflux;	72%
With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 18h; Product distribution / selectivity; Inert atmosphere;	94 %Chromat.
With palladium(II) acetylacetonate; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 16h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;	5.38 g
With potassium phosphate tribasic trihydrate; triphenylphosphine-3,3',3"-trisulfonic acid, trisodium salt; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; at 80 - 90 ℃; for 20h; Temperature; Time; Inert atmosphere;