What is the N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine?

N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine is , while it's Molecular Formula is C 16 H 10 F 2 N 6 O. BAM 15, is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.

What is the CAS number for N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine?

The CAS number of N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine is 210302-17-3.

What is N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (210302-17-3) used for?

BAM15 (210302-17-3) is a mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane.2 Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models.3 Reverses diet-induced obesity and insulin resistance in mice.4 Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.5

What is the N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine?

N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine is , while it's Molecular Formula is C 16 H 10 F 2 N 6 O. BAM 15, is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.

What is the CAS number for N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine?

The CAS number of N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine is 210302-17-3.

What is N 5 ,N 6 -bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (210302-17-3) used for?

BAM15 (210302-17-3) is a mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane.2 Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models.3 Reverses diet-induced obesity and insulin resistance in mice.4 Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.5

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210302-17-3

Product Name:BAM15
Molecular Weight:340.292

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Product Details

Purity:99%

Factory supply BAM15 210302-17-3 with sufficient production capacity

Molecular Formula:C₁₆H₁₀F₂N₆O
Molecular Weight:340.292
Boiling Point:421.7±55.0 °C(Predicted)
Density:1.548±0.06 g/cm3(Predicted)

210302-17-3 Relevant articles

Chemistry of furazano[3,4-b]pyrazines 3. Method for the synthesis of 5,6-disubstituted furazano[3,4-b]pyrazines

Starchenkov,Andrianov

, p. 1219 - 1233 (2007/10/03)

A method was developed for the synthesis...

210302-17-3 Process route

: 348-54-9
2-Fluoroaniline

: 153493-48-2
5,6-dichlorofurazano<3,4-b>pyrazine

: 210302-17-3
N⁵,N⁶-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

Conditions

Conditions	Yield
With N,N-diethylaniline; In acetonitrile; Heating;	64%

210302-17-3 Upstream products

348-54-9
2-Fluoroaniline
153493-48-2
5,6-dichlorofurazano<3,4-b>pyrazine

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