What is the BIBW2992 DiMaleate?

BIBW2992 DiMaleate is , while it's Molecular Formula is 2C 4 H 4 O 4 *C 24 H 25 ClFN 5 O 3 . Afatinib Dimaleate is a salt of Afatinib {BIBW 2992), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.

What is the CAS number for BIBW2992 DiMaleate?

The CAS number of BIBW2992 DiMaleate is 850140-73-7.

What is BIBW2992 DiMaleate (850140-73-7) used for?

Afatinib dimaleate was approved by the U.S. Food and DrugAdministration (FDA) in 2013 for the treatment of non-small celllung cancer (NSCLC). Specifically, it was approved for patientspresenting with metastatic NSCLC tumors which contain epidermalgrowth factor receptor (EGFR) exon deletions or exon 21mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosinekinases (tyk), which downregulates ErbB signaling by irreversiblebinding of EGFR tyk binding sites. While nomanufacturing route has been disclosed to date, the most scalablepublished route likely derives from two Boehringer Ingelheimpatents.

Product classification

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850140-73-7

Product Name:Afatinib dimaleate
Molecular Formula:C₂₄H₂₅ClFN₅O₃·2C₄H₄O₄
Molecular Weight:718.092

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Product Details

Purity:99%

Chinese factory supply Afatinib dimaleate 850140-73-7 in stock with high standard

Molecular Formula:2C₄H₄O₄*C₂₄H₂₅ClFN₅O₃
Molecular Weight:718.092
Boiling Point:983.1 °C at 760 mmHg
Flash Point:548.3 °C
PSA：241.30000
LogP:4.53600

850140-73-7 Relevant articles

Preparation method of quinazolinyl butylene amide compound

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Paragraph 0045; 0050; 0053; 0058; 0060; 0065; 0067; 0072, (2021/07/17)

The invention discloses a preparation me...

Arab league law for nepal preparation method of the compound

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, (2019/04/10)

The invention provides a novel preparati...

Preparation method of afatinib maleate

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, (2019/12/25)

The invention belongs to the technical f...

Novel afatinib dimaleate crystal form and preparation method and application thereof

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Paragraph 0031-0040, (2019/06/30)

The invention relates to a novel afatini...

850140-73-7 Process route

: 618061-76-0
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate

: 850140-73-7
2-butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-([(3S)-tetrahydro-3-furanyl]oxy)-6-quinazolinyl)-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 20 - 30 °C / Inert atmosphere 1.2: 2.5 h / -15 - 20 °C / Inert atmosphere 2.1: tetrahydrofuran / 1.03 h / 20 °C With hydrogenchloride; In tetrahydrofuran; water;

: 618061-76-0
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate

: 1398312-22-5,850140-73-7
afatinib fumarate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 20 - 30 °C / Inert atmosphere 1.2: 2.5 h / -15 - 20 °C / Inert atmosphere 2.1: ethanol / 20 - 70 °C With hydrogenchloride; In ethanol; water;

850140-73-7 Upstream products

850140-72-6
afatinib
110-16-7
maleic acid
618061-76-0
(S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate
314771-76-1
6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

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