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Purity:99%
This invention relates to the use of acy...
![5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid](/upload/2026/5/34199f33-b72e-4b1b-8e4a-a37b1ecc5b52.png)
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid
(S)-2-amino-3-cyclopentyl-N-(2-cyclopropyl)propanamide bis-hydrochloride
GSK2830371
| Conditions | Yield |
|---|---|
|
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid;
With
4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
(S)-2-amino-3-cyclopentyl-N-(2-cyclopropyl)propanamide bis-hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
76% |
(S)-2-((tert-butoxycarbonyl)amino)-3-cyclopentylpropanoic acid
GSK2830371
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1.1: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C
2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 20 °C
With
4-methyl-morpholine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; HATU;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
|
(S)-2-((tert-butoxycarbonyl)amino)-3-cyclopentylpropanoic acid
2,5-dichloro-3-nitropyridine
(S)-tert-butyl [3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl]carbamate
5-{[(5-chloro-2-methyl-3-pyridinyl)amino]methyl}-2-thiophenecarboxylic acid
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