What is the PKR-IN-1?

PKR-IN-1 is , while it's Molecular Formula is C 24 H 26 N 4 O 3 S. Used in Neurodegenerative Disease Treatment: PKR-IN-1 is used as a neuroprotective agent for its potential to treat conditions such as neurodegenerative diseases. Its anti-inflammatory and neuroprotective effects have been demonstrated in preclinical studies, suggesting its therapeutic potential in this area. Used in Viral Infection Treatment: PKR-IN-1 is used as an antiviral agent due to its ability to modulate the innate immune system, which may help in the treatment of viral infections. Used in Cancer Therapy: PKR-IN-1 is used as a therapeutic agent for cancer treatment, as its modulation of cellular pathways involved in inflammation and apoptosis may contribute to the management of cancerous conditions. Further research and clinical studies are needed to fully understand the potential applications and mechanisms of action of PKR-IN-1 in these areas.

What is the CAS number for PKR-IN-1?

The CAS number of PKR-IN-1 is 1260075-17-9.

What is PKR-IN-1 (1260075-17-9) used for?

PKR-IN-1 is a potent and selective inhibitor of the protein kinase double-stranded RNA-dependent protein kinase (PKR), which is an important regulator of cellular stress response and plays a critical role in the innate immune system. By inhibiting PKR, PKR-IN-1 can potentially modulate various cellular pathways and processes involved in inflammation, apoptosis, and autophagy.

What is the PKR-IN-1?

PKR-IN-1 is , while it's Molecular Formula is C 24 H 26 N 4 O 3 S. Used in Neurodegenerative Disease Treatment: PKR-IN-1 is used as a neuroprotective agent for its potential to treat conditions such as neurodegenerative diseases. Its anti-inflammatory and neuroprotective effects have been demonstrated in preclinical studies, suggesting its therapeutic potential in this area. Used in Viral Infection Treatment: PKR-IN-1 is used as an antiviral agent due to its ability to modulate the innate immune system, which may help in the treatment of viral infections. Used in Cancer Therapy: PKR-IN-1 is used as a therapeutic agent for cancer treatment, as its modulation of cellular pathways involved in inflammation and apoptosis may contribute to the management of cancerous conditions. Further research and clinical studies are needed to fully understand the potential applications and mechanisms of action of PKR-IN-1 in these areas.

What is the CAS number for PKR-IN-1?

The CAS number of PKR-IN-1 is 1260075-17-9.

What is PKR-IN-1 (1260075-17-9) used for?

PKR-IN-1 is a potent and selective inhibitor of the protein kinase double-stranded RNA-dependent protein kinase (PKR), which is an important regulator of cellular stress response and plays a critical role in the innate immune system. By inhibiting PKR, PKR-IN-1 can potentially modulate various cellular pathways and processes involved in inflammation, apoptosis, and autophagy.

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1260075-17-9

Product Name:Mitapivat
Molecular Weight:450.561

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Product Details

Purity:99%

Factory Sells Best Quality Mitapivat 1260075-17-9 with steady supply

Molecular Formula:C₂₄H₂₆N₄O₃S
Molecular Weight:450.561
Boiling Point:667.3±65.0 °C(Predicted)
PKA:6.69±0.50(Predicted)
Density:1.369±0.06 g/cm3(Predicted)

1260075-17-9 Relevant articles

CRYSTALLINE FORMS OF N-(4-(4-(CYCLOPROPYLMETHYL) PIPERAZINE-1-CARBONYL)PHENYL)QUINOLINE-8-SULFONAMIDE

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Paragraph 00173, (2019/06/11)

Provided herein are amorphous and crysta...

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

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Page/Page column 90-91, (2011/01/05)

Compounds and compositions comprising co...

1260075-17-9 Process route

: 116834-64-1
4-(quinoline-8-sulfonamido)benzoic acid

: 373608-42-5
1-(cyclopropylmethyl)piperazine dihydrochloride

: 1260075-17-9
N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Conditions

Conditions	Yield
4-(quinoline-8-sulfonamido)benzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl acetamide; at 25 ℃; for 2h; Inert atmosphere; 1-(cyclopropylmethyl)piperazine dihydrochloride; at 25 ℃; for 4h;	90%

: 18704-37-5
quinoline-8-sulfonyl chloride

: 1260075-17-9
N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: pyridine / acetonitrile / 5 h / 20 - 65 °C 2.1: sodium hydroxide; water / 3 h / 75 - 80 °C 3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl acetamide / 2 h / 25 °C / Inert atmosphere 3.2: 4 h / 25 °C With pyridine; water; 1,1'-carbonyldiimidazole; sodium hydroxide; In N,N-dimethyl acetamide; acetonitrile;

1260075-17-9 Upstream products

116834-64-1
4-(quinoline-8-sulfonamido)benzoic acid
373608-42-5
1-(cyclopropylmethyl)piperazine dihydrochloride
208175-71-7
ethyl 4-(quinoline-8-sulfonamido)benzoate
94-09-7
p-aminoethylbenzoate

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