915087-33-1

Chinese Manufacturer supply Enzalutamide 915087-33-1 in stock with high standard We supply high quality MDV-3100 (CAS 915087-33-1), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the MDV-3100 ?

MDV-3100 is , while it's Molecular Formula is C21H16F4N4O2S. MDV3100, known as Enzalutamide, is a second-generation androgen receptor (AR) signaling inhibitor. It is able to inhibit binding of androgens to the AR, AR nuclear translocation, and the association of the AR with DNA.

What is the CAS number for MDV-3100 ?

The CAS number of MDV-3100 is 915087-33-1.

More information of MDV-3100 915087-33-1 are:

What is MDV-3100 (915087-33-1) used for?

In August 2012, the US FDA approved enzalutamide for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who have previously been treated with docetaxel. Synthesis of enzalutamide was achieved by a triply convergent route that employed a Strecker condensation, followed by isothiocyanate condensation and hydrolysis to form the thiohydantoin moiety. In LNCaP/AR cells with high expression of AR, enzalutamide demonstrated potent inhibition of 16b-[18F]-5α-dihydrotestosterone binding (IC50=21 nM compared with bicalutamide IC50=160 nM), and inhibited AR translocation to the nucleus more potently than bicalutamide.The primary metabolite is the result of CYP2C8-mediated N-demethylation; enzalutamide is primarily eliminated by hepatic metabolism.

InChI:InChI=1/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)

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How to get the best price on MDV-3100?

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