What is the Sancycline?

Sancycline is , while it's Molecular Formula is C 21 H 22 N 2 O 7 . Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).

What is the CAS number for Sancycline?

The CAS number of Sancycline is 808-26-4.

What is Sancycline (808-26-4) used for?

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.InChI:InChI=1/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24-25,29-30H,6-7,22H2,1-2H3/b20-14+/t9-,10-,15-,21-/m0/s1

What is the Sancycline?

Sancycline is , while it's Molecular Formula is C 21 H 22 N 2 O 7 . Sancycline is a tetracycline bacteriostatic antibiotic which also binds to the Tet repressor protein (TetR).

What is the CAS number for Sancycline?

The CAS number of Sancycline is 808-26-4.

What is Sancycline (808-26-4) used for?

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.InChI:InChI=1/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24-25,29-30H,6-7,22H2,1-2H3/b20-14+/t9-,10-,15-,21-/m0/s1

Product classification

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808-26-4

Product Name:Sancycline
Molecular Formula:C₂₁H₂₂N₂O₇
Molecular Weight:414.415

Inquiry

Product Details

pd_meltingpoint:224-228 °C (dec)

Purity:99%

Manufacturer supply high quality Sancycline 808-26-4 with GMP standards

Molecular Formula:C₂₁H₂₂N₂O₇
Molecular Weight:414.415
Vapor Pressure:3E-17mmHg at 25°C
Melting Point:224-228 °C (dec)
Refractive Index:1.734
Boiling Point:750.9 °C at 760 mmHg
PKA:4.50±1.00(Predicted)
Flash Point:407.9 °C
PSA：161.39000
Density:1.61 g/cm³
LogP:0.82090

Sancycline(Cas 808-26-4) Usage

Brand name

Bonomycin (Pfizer).

InChI:InChI=1/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24-25,29-30H,6-7,22H2,1-2H3/b20-14+/t9-,10-,15-,21-/m0/s1

808-26-4 Relevant articles

Preparation process of 6-demethyl-6-deoxytetracycline

-

Paragraph 0037; 0045; 0047-0049; 0051-0053; 0055-0057; 0059, (2020/07/15)

The invention discloses a preparation pr...

Preparation method of minocycline hydrochloride

-

Paragraph 0056; 0062; 0070; 0077; 0092; 0099, (2017/08/30)

The invention provides a preparation met...

A mountain of tigecycline preparation method

-

Paragraph 0031; 0032; 0033; 0034; 0035; 0036-0050, (2017/06/19)

The invention discloses a preparation me...

SEMI-SYNTHESIS PROCEDURES

-

Paragraph 00176, (2016/05/24)

Provided herein are improved processes t...

808-26-4 Process route

: 987-02-0
6-demethyltetracycline

: 808-26-4,2696-12-0,15964-02-0,39105-46-9
sancycline

Conditions

Conditions	Yield
With methanesulfonic acid; 5%-palladium/activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide; at 30 - 35 ℃; for 5h; under 3000.3 - 6000.6 Torr; Solvent; Temperature; Reagent/catalyst;	90.7%
With rhodium contaminated with carbon; hydrogen; toluene-4-sulfonic acid; In methanol; at -5 - 5 ℃; Temperature;

: 127-33-3
Demeclocycline

: 808-26-4,2696-12-0,15964-02-0,39105-46-9
sancycline

Conditions

Conditions	Yield
With 10% rhodium on carbon; hydrogen; toluene-4-sulfonic acid; In methanol; at 20 ℃; for 15h; under 11251.1 - 18751.9 Torr; Reagent/catalyst; Pressure; Solvent; Autoclave;	88%

808-26-4 Upstream products

5679-00-5
7-amino-6-desmethyl-6-deoxytetracycline
64-19-7
acetic acid
127-33-3
Demeclocycline
64-73-3
demeclocycline hydrochloride

808-26-4 Downstream products

5585-59-1
[4S-(4a,12aα)]-7-nitro-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a octahydro-naphthacene-2-carboxylic acid amide
5679-00-5
7-amino-6-desmethyl-6-deoxytetracycline
13614-98-7
minocycline Hydrochloride

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