K 02288 is , while it's Molecular Formula is C20H20N2O4. K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.

What is the CAS number for K 02288?

The CAS number of K 02288 is 1431985-92-0.

What is K 02288 (1431985-92-0) used for?

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, K 02288 can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

K 02288 is , while it's Molecular Formula is C20H20N2O4. K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.

What is the CAS number for K 02288?

The CAS number of K 02288 is 1431985-92-0.

What is K 02288 (1431985-92-0) used for?

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, K 02288 can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

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1431985-92-0

Product Name:K02288
Molecular Formula:C20H20N2O4
Molecular Weight:352.38

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Product Details

Purity:99%

99% Purity Commercial production K02288 1431985-92-0 with Cheapest Price

Molecular Formula:C20H20N2O4
Molecular Weight:352.38
Boiling Point:522.2±50.0 °C(Predicted)
PKA:9.33±0.10(Predicted)
PSA：86.83000
Density:1.232±0.06 g/cm3(Predicted)
LogP:4.31040

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