What is the Kartogenin?

Kartogenin is , while it's Molecular Formula is C20H15NO3. Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.

What is the CAS number for Kartogenin?

The CAS number of Kartogenin is 4727-31-5.

What is Kartogenin (4727-31-5) used for?

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.

What is the Kartogenin?

Kartogenin is , while it's Molecular Formula is C20H15NO3. Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.

What is the CAS number for Kartogenin?

The CAS number of Kartogenin is 4727-31-5.

What is Kartogenin (4727-31-5) used for?

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.

Product classification

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：WhatsApp: +86 15965530500
Website：https://www.shandonghangyubiotech.com
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

4727-31-5

Product Name:KGN，Kartogenin
Molecular Formula:C20H15NO3
Molecular Weight:317.344

Inquiry

Product Details

pd_meltingpoint:272 °C

Purity:99%

Chinese factory supply KGN，Kartogenin 4727-31-5 in stock with high standard

Molecular Formula:C20H15NO3
Molecular Weight:317.344
Melting Point:272 °C
Boiling Point:464.4±38.0 °C(Predicted)
PKA:3.45±0.36(Predicted)
PSA：66.40000
Density:1.289±0.06 g/cm3(Predicted)
LogP:4.37710

4727-31-5 Relevant articles

Compounds and methods for inducing chondrogenesis

-

Page/Page column 38; 65; 66, (2016/10/31)

The present invention provides compounds...

NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS

-

Page/Page column 37, (2011/11/13)

The present invention provides dihydroor...

NOVEL IMMUNOMODULATOR AND ANTI INFLAMMATORY COMPOUNDS

-

Page/Page column 71, (2011/11/30)

The present invention provides dihydroor...

Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same

-

, (2008/06/13)

The invention relates to transport molec...

4727-31-5 Process route

: 4727-31-5
kartogenin

Conditions

Conditions	Yield



With dmap; In tetrahydrofuran; chloroform; at 20 ℃;

: 4727-31-5
kartogenin

: 75-04-7,85404-22-4
ethylamine

: C₂₂H₂₀N₂O₂

Conditions

Conditions	Yield
kartogenin; ethylamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Relevant Products

JORO SPIDER TOXIN JSTX-3
CAS：112163-33-4
cis-13-Docosenoamide
CAS：112-84-5
Galloflavin
CAS：568-80-9
ML261
CAS：902523-58-4