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920509-33-7

  • Product Name:WXG00198
  • Molecular Weight:481.295
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Product Details

Purity:99%

Manufacturer supply high quality WXG00198 920509-33-7 with ISO standards

  • Molecular Formula:C19H18Cl2N6O5
  • Molecular Weight:481.295

920509-33-7 Relevant articles

Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3- yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia

Kelly, Martha J.,Pietranico-Cole, Sherrie,Larigan, J. Douglas,Haynes, Nancy-Ellen,Reynolds, Charles H.,Scott, Nathan,Vermeulen, John,Dvorozniak, Mark,Conde-Knape, Karin,Huang, Kuo-Sen,So, Sung-Sau,Thakkar, Kshitij,Qian, Yimin,Banner, Bruce,Mennona, Frank,Danzi, Sara,Klein, Irwin,Taub, Rebecca,Tilley, Jefferson

, p. 3912 - 3923 (2014/06/09)

The beneficial effects of thyroid hormon...

920509-33-7 Process route

6-(4-amino-2,6-dichlorophenoxy)-4-isopropyl-pyridazin-3(2H)-one
920509-28-0

6-(4-amino-2,6-dichlorophenoxy)-4-isopropyl-pyridazin-3(2H)-one

N-cyanoacetylurethane
68168-42-3

N-cyanoacetylurethane

ethyl(2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate
920509-33-7

ethyl(2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate

Conditions
Conditions Yield
6-(4-amino-2,6-dichlorophenoxy)-4-isopropyl-pyridazin-3(2H)-one; With hydrogenchloride; sodium nitrate; In water; at 0 ℃; for 0.5h;
N-cyanoacetylurethane; With pyridine; In water; at 0 ℃;
76%
3,6-dichloro-4-isopropyl-1,2-dihydropyridazine
107228-51-3

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine

ethyl(2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate
920509-33-7

ethyl(2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere
2.1: acetic acid; sodium acetate / 24 h / 100 °C / Inert atmosphere
2.2: 24 h / 120 °C / Inert atmosphere
3.1: sodium nitrate; hydrogenchloride / water / 0.5 h / 0 °C
3.2: 0 °C
With hydrogenchloride; sodium nitrate; copper(l) iodide; sodium acetate; potassium carbonate; acetic acid; In water; dimethyl sulfoxide;
 

920509-33-7 Upstream products

  • 920509-28-0
    920509-28-0

    6-(4-amino-2,6-dichlorophenoxy)-4-isopropyl-pyridazin-3(2H)-one

  • 68168-42-3
    68168-42-3

    N-cyanoacetylurethane

  • 107228-51-3
    107228-51-3

    3,6-dichloro-4-isopropyl-1,2-dihydropyridazine

  • 5930-28-9
    5930-28-9

    4-amino-2,6-dichlorophenol

920509-33-7 Downstream products

  • 920509-32-6
    920509-32-6

    2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile

  • 920509-35-9
    920509-35-9

    2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid

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