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Purity:99%
GPR120 is a receptor of unsaturated long...
3-(4-hydroxyphenyl)propionic acid methyl ester
![3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid](/upload/2025/4/bcceab8b-dd5f-4047-9b53-330f2e4d8344.png)
3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; acetonitrile / 20 h / 75 °C / Inert atmosphere
3: water; lithium hydroxide / tetrahydrofuran / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); water; potassium carbonate; potassium iodide; lithium hydroxide;
In
tetrahydrofuran; water; acetone; acetonitrile;
2: Suzuki coupling;
|
![methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate](/upload/2025/4/a66bf0a6-b5cc-4056-8c18-18bb8a6fe7ed.png)
methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate
3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid
| Conditions | Yield |
|---|---|
|
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
|
94% |
5-fluoro-2-bromobenzyl chloride
methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate
3-(4-hydroxyphenyl)propionic acid methyl ester
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