What is the 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID?

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID is , while it's Molecular Formula is C21H17NO3. BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.

What is 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID (321674-73-1) used for?

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.InChI:InChI=1/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+

What is the 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID?

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID is , while it's Molecular Formula is C21H17NO3. BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.

What is 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID (321674-73-1) used for?

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.InChI:InChI=1/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+

Product classification

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321674-73-1

Q: What is the CAS number for 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID?

The CAS number of 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID is 321674-73-1.

Product Name:BIBR1532
Molecular Formula:C₂₁H₁₇NO₃
Molecular Weight:331.36

Inquiry

Product Details

Purity:99%

Chinese factory supply BIBR1532 321674-73-1 in stock with high standard

Molecular Formula:C21H17NO3
Molecular Weight:331.36
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.698
Boiling Point:600.607 °C at 760 mmHg
PKA:3.46±0.36(Predicted)
Flash Point:317.036 °C
PSA：66.40000
Density:1.285 g/cm³
LogP:4.65300

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID(Cas 321674-73-1) Usage

Biological Activity

Selective telomerase inhibitor (IC 50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

references

[1]. damm, k.; hemmann, u.; garin-chesa, p.; hauel, n.; kauffman, i.; priepke, h.; niestroj, c.; daiber, c.; enenkel, b.; guilliard, b.; lauritsch, i.; muller, e.; pascolo, e.; sauter, g.; pantic, m.; martens, u. m.; wenz, c.; linger, j.; kraut, n.; rettig, w. j.;schnapp, a. a highly selective telomerase inhibitor limiting human cancer cell proliferation. embo j. 2001, 20, 6958?6968.[2]. bashash d1, ghaffari sh, mirzaee r, alimoghaddam k, ghavamzadeh a. telomerase inhibition by non-nucleosidic compound bibr1532 causes rapid cell death in pre-b acute lymphoblastic leukemia cells. leuk lymphoma. 2013 mar;54[4]:561-8. doi: 10.3109/10428194.2012.704034. epub 2012 sep 28.[3]. bashash d1, ghaffari sh, zaker f, kazerani m, hezave k, hassani s, rostami m, alimoghaddam k, ghavamzadeh a. anticancer agents med chem. 2013 sep;13(7):1115-25. bibr 1532 increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells: therapeutic potential for apl.

InChI:InChI=1/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+

321674-73-1 Relevant articles

TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF

-

Paragraph 00127; 00128, (2020/12/30)

The present disclosure provides TERT inh...

N-substituted acrylamide derivatives as DHODH inhibitors and preparation and use of N-substituted acrylamide derivatives

-

Paragraph 0178-0179; 0183; 0320-0322, (2019/11/04)

The invention relates to N-substituted a...

Inhibition of telomerase by BIBR 1532 and related analogues

Barma,Elayadi, Anissa,Falck,Corey, David R.

, p. 1333 - 1336 (2007/10/03)

BIBR 1532 has been reported to be a pote...

Carboxylic acid amides, pharmaceutical compositions containing these compounds and their use

-

, (2008/06/13)

Carboxylic acid amides of general formul...

321674-73-1 Process route

: 565190-73-0
N-(2-carbomethoxyphenyl)-3-(naphthalen-2-yl)-but-2(Z)-enamide

: 321674-73-1
trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide

Conditions

Conditions	Yield
With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;
With sodium hydroxide; In ethanol;

: 321674-72-0
N-(2-carbomethoxyphenyl)-3-(naphthalen-2-yl)-but-2(E)-enamide

: 321674-73-1
2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-butenyl-1-yl]amino]benzoic acid

Conditions

Conditions	Yield
With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;
With water; lithium hydroxide; In tetrahydrofuran; methanol;

321674-73-1 Upstream products

565190-73-0
N-(2-carbomethoxyphenyl)-3-(naphthalen-2-yl)-but-2(Z)-enamide
51212-51-2
methyl (Z)-3-(naphthalen-2-yl)-but-2-enoate
93-08-3
methyl 2-naphthyl ketone
321674-72-0
N-(2-carbomethoxyphenyl)-3-(naphthalen-2-yl)-but-2(E)-enamide

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