What is the 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione?

6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is , while it's Molecular Formula is C20H25ClN4O2. Used in Pharmaceutical Industry: ML-180 is used as a therapeutic agent for the treatment of breast cancer, specifically targeting estrogen-receptor negative MDA-MB-231 breast cancer cells. Its mechanism of action involves modulating the expression of haptoglobin and serum amyloid proteins A1 and A4, as well as inhibiting the steroidogenic acute regulatory promoter. Used in Drug Development: ML-180 is used as a research tool for studying the role of liver receptor homolog-1 (LRH-1) in various biological processes and its potential as a target for drug development. Its inverse agonist activity and specificity for LRH-1 make it a valuable compound for investigating the therapeutic potential of modulating LRH-1 activity in different diseases and conditions.

What is the CAS number for 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione?

The CAS number of 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is 863588-32-3.

What is 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione (863588-32-3) used for?

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 μM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 μM).

What is the 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione?

6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is , while it's Molecular Formula is C20H25ClN4O2. Used in Pharmaceutical Industry: ML-180 is used as a therapeutic agent for the treatment of breast cancer, specifically targeting estrogen-receptor negative MDA-MB-231 breast cancer cells. Its mechanism of action involves modulating the expression of haptoglobin and serum amyloid proteins A1 and A4, as well as inhibiting the steroidogenic acute regulatory promoter. Used in Drug Development: ML-180 is used as a research tool for studying the role of liver receptor homolog-1 (LRH-1) in various biological processes and its potential as a target for drug development. Its inverse agonist activity and specificity for LRH-1 make it a valuable compound for investigating the therapeutic potential of modulating LRH-1 activity in different diseases and conditions.

What is the CAS number for 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione?

The CAS number of 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is 863588-32-3.

What is 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione (863588-32-3) used for?

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 μM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 μM).

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Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

863588-32-3

Product Name:ML-180
Molecular Formula:C20H25ClN4O2
Molecular Weight:388.9

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Product Details

Purity:99%

Good factory supply good ML-180 863588-32-3

Molecular Formula:C20H25ClN4O2
Molecular Weight:388.9
PKA:9.37±0.40(Predicted)

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