What is the (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine?

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is , while it's Molecular Formula is C31H42N4O6. (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

What is the CAS number for (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine?

The CAS number of (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is 868540-16-3.

What is (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine (868540-16-3) used for?

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine, also known as (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid, is a complex organic compound that serves as an intermediate in the synthesis of Carfilzomib (C183460). (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine plays a crucial role in the development of second-generation proteasome inhibitors, which are significant in the field of oncology. Used in Pharmaceutical Industry: (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is used as an intermediate compound for the synthesis of Carfilzomib, a second-generation proteasome inhibitor. It is utilized for the development of treatments targeting relapsed and refractory multiple myeloma, a type of blood cancer. (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine contributes to the creation of drugs that can effectively combat this disease by inhibiting the activity of the proteasome, a cellular component essential for the degradation of damaged or unneeded proteins. This inhibition can lead to the accumulation of misfolded proteins, ultimately triggering cell death in cancerous cells.

What is the (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine?

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is , while it's Molecular Formula is C31H42N4O6. (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

What is the CAS number for (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine?

The CAS number of (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is 868540-16-3.

What is (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine (868540-16-3) used for?

(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine, also known as (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid, is a complex organic compound that serves as an intermediate in the synthesis of Carfilzomib (C183460). (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine plays a crucial role in the development of second-generation proteasome inhibitors, which are significant in the field of oncology. Used in Pharmaceutical Industry: (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is used as an intermediate compound for the synthesis of Carfilzomib, a second-generation proteasome inhibitor. It is utilized for the development of treatments targeting relapsed and refractory multiple myeloma, a type of blood cancer. (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine contributes to the creation of drugs that can effectively combat this disease by inhibiting the activity of the proteasome, a cellular component essential for the degradation of damaged or unneeded proteins. This inhibition can lead to the accumulation of misfolded proteins, ultimately triggering cell death in cancerous cells.

Product classification

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：WhatsApp: +86 15965530500
Website：https://www.shandonghangyubiotech.com
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

868540-16-3

Product Name:Carfilzomib Acid Intermediate
Molecular Formula:C31H42N4O6
Molecular Weight:566.698

Inquiry

Product Details

Purity:99%

High Quality Chinese Factory supply 868540-16-3 Carfilzomib Acid Intermediate

Molecular Formula:C31H42N4O6
Molecular Weight:566.698
Boiling Point:865.6±65.0 °C(Predicted)
PKA:3.50±0.10(Predicted)
PSA：137.07000
Density:1.190±0.06 g/cm3(Predicted)
LogP:2.88980

868540-16-3 Relevant articles

Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy to Overcome Cancer Resistance to Carfilzomib and Bortezomib

Lee, Min Jae,Bhattarai, Deepak,Yoo, Jisu,Miller, Zach,Park, Ji Eun,Lee, Sukyeong,Lee, Wooin,Driscoll, James J.,Kim, Kyung Bo

, p. 4444 - 4455 (2019/05/08)

Over the past 15 years, proteasome inhib...

Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors

Lei, Meng,Zhang, Haoyang,Miao, Hang,Du, Xiao,Zhou, Hui,Wang, Jia,Wang, Xueyuan,Feng, Huayun,Shi, Jingmiao,Liu, Zhaogang,Shen, Jian,Zhu, Yongqiang

, p. 4151 - 4162 (2019/08/07)

A series of novel tetrapeptidyl epoxyket...

AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

-

Page/Page column 64, (2016/12/07)

The present invention relates to an impr...

PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE

-

, (2016/11/14)

The present invention relates to process...

868540-16-3 Process route

: 868539-99-5
C₂HF₃O₂*C₂₆H₃₅N₃O₄

: 868540-16-3
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C 2: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Yield

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

2: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

: 875309-92-5
(S)-benzyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoate

: 868540-16-3
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid

Conditions

Conditions	Yield
With methanol; hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 2h; under 760.051 Torr;
With palladium on activated charcoal; ammonium formate; In methanol; at 25 - 30 ℃; for 2h; Solvent; Reagent/catalyst;	77 g
With 5 mol% Pd/C; hydrogen; In methanol; for 0.5h;

868540-16-3 Upstream products

875309-92-5
(S)-benzyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoate
13139-15-6
N-tert-butoxycarbonyl-L-leucine
2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate
15136-32-0
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

868540-16-3 Downstream products

868540-17-4
carfilzomib

Relevant Products

JORO SPIDER TOXIN JSTX-3
CAS：112163-33-4
cis-13-Docosenoamide
CAS：112-84-5
ML179
CAS：1883548-87-5
Anthranilamide
CAS：88-68-6