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1020149-73-8

  • Product Name:SGI-1027
  • Molecular Formula:C27H23N7O
  • Molecular Weight:461.526
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Product Details

pd_meltingpoint:>280℃

Purity:99%

Cost-effective and customizable SGI-1027 1020149-73-8 supplier

  • Molecular Formula:C27H23N7O
  • Molecular Weight:461.526
  • Melting Point:>280℃ 
  • PKA:13.31±0.70(Predicted) 
  • PSA：125.30000 
  • Density:1.387±0.06 g/cm3(Predicted) 
  • LogP:5.46390 

1020149-73-8 Relevant articles

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells

Valente, Sergio,Liu, Yiwei,Schnekenburger, Michael,Zwergel, Clemens,Cosconati, Sandro,Gros, Christina,Tardugno, Maria,Labella, Donatella,Florean, Cristina,Minden, Steven,Hashimoto, Hideharu,Chang, Yanqi,Zhang, Xing,Kirsch, Gilbert,Novellino, Ettore,Arimondo, Paola B.,Miele, Evelina,Ferretti, Elisabetta,Gulino, Alberto,Diederich, Marc,Cheng, Xiaodong,Mai, Antonello

, p. 701 - 713 (2014/03/21)

DNA methyltransferases (DNMTs) are impor...

Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line

García-Domínguez, Patricia,Dell'Aversana, Carmela,Alvarez, Rosana,Altucci, Lucia,De Lera, ángel R.

, p. 1631 - 1635 (2013/04/10)

The known DNMT inhibitor SGI-1027 4 has ...

1020149-73-8 Process route

N<SUP>4</SUP>-(4-aminophenyl)-6-methyl-2,4-diamino-pyrimidine
20719-43-1

N4-(4-aminophenyl)-6-methyl-2,4-diamino-pyrimidine

4-(quinolin-4-ylamino)benzoic acid
133041-90-4

4-(quinolin-4-ylamino)benzoic acid

N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
1020149-73-8

N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide

Conditions
Conditions Yield
4-(quinolin-4-ylamino)benzoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;
N4-(4-aminophenyl)-6-methyl-2,4-diamino-pyrimidine; In N,N-dimethyl-formamide; Inert atmosphere;
79%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 65 ℃; for 24h; Inert atmosphere;
59%
2-amino-6-methyl-4-chloropyrimidine
5600-21-5

2-amino-6-methyl-4-chloropyrimidine

N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
1020149-73-8

N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol; water / 1.5 h / 110 °C / Sealed tube; Inert atmosphere
2: hydrogen / ethanol / 24 h / Inert atmosphere
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 65 °C / Inert atmosphere
With hydrogen; palladium diacetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; XPhos; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: |Buchwald-Hartwig Coupling;
Multi-step reaction with 5 steps
1: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol; water / 1.5 h / 110 °C / Sealed tube; Inert atmosphere
2: hydrogen / ethanol / 24 h / Inert atmosphere
3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4: acetic acid; decaborane; palladium 10% on activated carbon / methanol / 2 h / Inert atmosphere; Reflux
5: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol; water; N,N-dimethyl-formamide / 24 h / 110 °C / Sealed tube; Inert atmosphere
With decaborane; palladium 10% on activated carbon; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; acetic acid; XPhos; In methanol; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: |Buchwald-Hartwig Coupling / 5: |Buchwald-Hartwig Coupling;
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethanol / 2 h / 80 °C
2.1: hydrogenchloride; stannous chloride dihydrate / ethanol; water / 1 h / 0 - 80 °C
3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
With hydrogenchloride; stannous chloride dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In ethanol; water; N,N-dimethyl-formamide;

1020149-73-8 Upstream products

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    611-35-8

    4-chloroquinoline

  • 5600-21-5
    5600-21-5

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