What is the Reboxetine mesylate?

Reboxetine mesylate is tan or off-white cyrstalline solid, while it's Molecular Formula is CH 4 O 3 S*C 19 H 23 NO 3 . tan or off-white cyrstalline solid Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:to study its effects on the surge of dopamine in the cortex of mice brainto study its anti-immobility effects on the behavior of miceto analyze its effects on the probabilistic reversal learning task in rodents

What is the CAS number for Reboxetine mesylate?

The CAS number of Reboxetine mesylate is 98769-84-7.

What is Reboxetine mesylate (98769-84-7) used for?

Reboxetine mesylate is a selective noradrenaline reuptake inhibitor and an antidepressant medication.InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1

What is the Reboxetine mesylate?

Reboxetine mesylate is tan or off-white cyrstalline solid, while it's Molecular Formula is CH 4 O 3 S*C 19 H 23 NO 3 . tan or off-white cyrstalline solid Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:to study its effects on the surge of dopamine in the cortex of mice brainto study its anti-immobility effects on the behavior of miceto analyze its effects on the probabilistic reversal learning task in rodents

What is the CAS number for Reboxetine mesylate?

The CAS number of Reboxetine mesylate is 98769-84-7.

What is Reboxetine mesylate (98769-84-7) used for?

Reboxetine mesylate is a selective noradrenaline reuptake inhibitor and an antidepressant medication.InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1

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98769-84-7

Product Name:Reboxetine mesylate
Molecular Formula:C₁₉H₂₃NO₃^.CH₄O₃S
Molecular Weight:409.503
Appearance:tan or off-white cyrstalline solid

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Product Details

pd_meltingpoint:170-171°C

Appearance:tan or off-white cyrstalline solid

Purity:99%

Quality Factory Supply 99% Pure Reboxetine mesylate 98769-84-7 with Efficient Delivery

Molecular Formula:CH₄O₃S*C₁₉H₂₃NO₃
Molecular Weight:409.503
Appearance/Colour:tan or off-white cyrstalline solid
Vapor Pressure:4.54E-08mmHg at 25°C
Melting Point:170-171°C
Boiling Point:443.7 °C at 760 mmHg
Flash Point:188.2 °C
PSA：102.47000
LogP:4.10740

Reboxetine mesylate(Cas 98769-84-7) Usage

Biochem/physiol Actions

Reboxetine?exhibits anti-depressant activity.

InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1

98769-84-7 Relevant articles

The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate

Assaf, Georges,Checksfield, Graham,Critcher, Doug,Dunn, Peter J.,Field, Stuart,Harris, Laurence J.,Howard, Roger M.,Scotney, Gemma,Scott, Adam,Mathew, Suju,Walker, Geoffrey M. H.,Wilder, Alexander

, p. 123 - 129 (2012/04/11)

The Pfizer Green Chemistry metrics progr...

Process development and scale-up for (±)-reboxetine mesylate

Henegar, Kevin E.,Ball, Cynthia T.,Horvath, Carolyn M.,Maisto, Keith D.,Mancini, Sarah E.

, p. 346 - 353 (2012/12/31)

Redevelopment of the commercial process ...

Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124

Melloni,Della Torre,Lazzari,et al.

, p. 1393 - 1399 (2007/10/02)

98769-84-7 Process route

: 2-chloro-N-[3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]acetamide

: 93851-87-7,98769-82-5,98769-84-7,98819-77-3,105017-39-8,141425-90-3
Reboxetine mesylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol 2: methanesulfonic acid / acetone With methanesulfonic acid; potassium tert-butylate; In isopropyl alcohol; acetone; tert-butyl alcohol;
Multi-step reaction with 3 steps 1: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / Large scale 2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / Large scale 3: acetone / 1 h / 0 - 5 °C / Large scale With potassium tert-butylate; sodium bis(2-methoxyethoxy)aluminium dihydride; In isopropyl alcohol; acetone; toluene; tert-butyl alcohol;

Yield

Multi-step reaction with 2 steps

1: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol

2: methanesulfonic acid / acetone

With methanesulfonic acid; potassium tert-butylate; In isopropyl alcohol; acetone; tert-butyl alcohol;

Multi-step reaction with 3 steps

1: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / Large scale

2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / Large scale

3: acetone / 1 h / 0 - 5 °C / Large scale

With potassium tert-butylate; sodium bis(2-methoxyethoxy)aluminium dihydride; In isopropyl alcohol; acetone; toluene; tert-butyl alcohol;

: 93853-04-4,98769-75-6
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

: 93851-87-7,98769-82-5,98769-84-7,98819-77-3,105017-39-8,141425-90-3
Reboxetine mesylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: carbonic acid dimethyl ester / ethanol 2: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol 3: methanesulfonic acid / acetone With methanesulfonic acid; potassium tert-butylate; carbonic acid dimethyl ester; In ethanol; isopropyl alcohol; acetone; tert-butyl alcohol;
Multi-step reaction with 4 steps 1: triethylamine; carbonic acid dimethyl ester / 0.5 h / 4 - 10 °C / Large scale 2: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / Large scale 3: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / Large scale 4: acetone / 1 h / 0 - 5 °C / Large scale With potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; carbonic acid dimethyl ester; In isopropyl alcohol; acetone; toluene; tert-butyl alcohol;

Yield

Multi-step reaction with 3 steps

1: carbonic acid dimethyl ester / ethanol

2: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol

3: methanesulfonic acid / acetone

With methanesulfonic acid; potassium tert-butylate; carbonic acid dimethyl ester; In ethanol; isopropyl alcohol; acetone; tert-butyl alcohol;

Multi-step reaction with 4 steps

1: triethylamine; carbonic acid dimethyl ester / 0.5 h / 4 - 10 °C / Large scale

2: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / Large scale

3: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / Large scale

4: acetone / 1 h / 0 - 5 °C / Large scale

With potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; carbonic acid dimethyl ester; In isopropyl alcohol; acetone; toluene; tert-butyl alcohol;

98769-84-7 Upstream products

75-75-2
methanesulfonic acid
71620-89-8
reboxetine
94-71-3
2-Ethoxyphenol
93853-04-4
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

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